Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 263805, 8 pages
http://dx.doi.org/10.1155/2013/263805
Research Article

Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study

1D2L Pharma Research Centre, Bangalore 560 037, India
2NICS, Seoul 135-763, Republic of Korea
3Korea Polytechnic University, Siheung-Si 429-793, Republic of Korea
4Research and Development Centre, Natural Remedies, Plot No.5B, Veerasandra Indl. Area, 19th K.M. Stone, Hosur Road, Electronic City, Bangalore, Karnataka 560 100, India
5Anasuya Ayurveda Centre, Bangalore 560 050, India

Received 3 December 2012; Revised 11 February 2013; Accepted 11 February 2013

Academic Editor: Byung-Cheul Shin

Copyright © 2013 Sreenivasulu Puram et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. B. Marshall, One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and Its Association With Peptic Ulcer Disease Chapter 3, ASM Press, Washington, DC, USA, 2001.
  2. R. H. Hunt, S. D. Xiao, F. Megraud et al., “Helicobacter pylori in developing countries,” Journal of Gastrointestinal and Liver Diseases, vol. 20, no. 3, pp. 299–304, 2011. View at Google Scholar
  3. A. Nomura, G. N. Stemmermann, P. H. Chyou, G. I. Perez-Perez, and M. J. Blaser, “Helicobacter pylori infection and the risk for duodenal and gastric ulceration,” Annals of Internal Medicine, vol. 120, no. 12, pp. 977–981, 1994. View at Google Scholar · View at Scopus
  4. M. A. Adamu, B. Schottker, M. N. Weck, and H. Brenner, “Helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study,” Clinical Gastroenterology and Hepatology, vol. 10, no. 5, pp. 487–493, 2012. View at Google Scholar
  5. W. Q. Dai, Y. Q. Zhou, L. Xu et al., “The Eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study,” Hepato-Gastroenterology, vol. 59, no. 133, pp. 296–299, 2012. View at Google Scholar
  6. N. Uemura, S. Okamoto, S. Yamamoto et al., “Helicobacter pylori infection and the development of gastric cancer,” The New England Journal of Medicine, vol. 345, no. 11, pp. 784–789, 2001. View at Google Scholar
  7. L. Fuccio, R. M. Zagari, L. H. Eusebi et al., “Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?” Annals of Internal Medicine, vol. 151, no. 2, pp. 121–128, 2009. View at Google Scholar · View at Scopus
  8. C. Montalban, J. M. Castrillo, V. Abraira et al., “Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma. Clinicopathological study and evaluation of the prognostic factors in 143 patients,” Annals of Oncology, vol. 6, no. 4, pp. 355–362, 1995. View at Google Scholar · View at Scopus
  9. S. R. Owens and L. B. Smith, “Molecular aspects of H. pylori-related MALT lymphoma,” Pathology Research International, vol. 2011, Article ID 193149, 8 pages, 2011. View at Publisher · View at Google Scholar
  10. P. Malfertheiner, F. Megraud, C. O'Morain et al., “Current concepts in the management of Helicobacter pylori infection: the maastricht III consensus report,” Gut, vol. 56, no. 6, pp. 772–781, 2007. View at Google Scholar
  11. W. D. Chey and B. C. Wong, “American College of Gastroenterology guideline on the management of Helicobacter pylori infection,” The American Journal of Gastroenterology, vol. 102, no. 8, pp. 1808–1825, 2007. View at Google Scholar
  12. L. Fischbach and E. L. Evans, “Meta-analysis: The effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 3, pp. 343–357, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. V. De Francesco, F. Giorgio, C. Hassan et al., “Worldwide H. pylori antibiotic resistance: a systematic review,” Journal of Gastrointestinal and Liver Diseases, vol. 19, no. 4, pp. 409–414, 2010. View at Google Scholar
  14. C. Basset, J. Holton, L. Gatta et al., “Helicobacter pylori infection: anything new should we know?” Alimentary Pharmacology and Therapeutics, vol. 20, no. 2, pp. 31–41, 2004. View at Google Scholar · View at Scopus
  15. F. Mégraud, “H. pylori antibiotic resistance: prevalence, importance, and advances in testing,” Gut, vol. 53, no. 9, pp. 1374–1384, 2004. View at Google Scholar
  16. R. O'Mahony, H. Al-Khtheeri, D. Weerasekera et al., “Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori,” World Journal of Gastroenterology, vol. 11, no. 47, pp. 7499–7507, 2005. View at Google Scholar · View at Scopus
  17. H. Hikino, “Recent research on oriental medicinal plants,” in Economic and Medicinal Plant Research, H. Wagner, H. Hikino, and N. R. Farnsworth, Eds., pp. 53–85, Academic Press, London, UK, 1985. View at Google Scholar
  18. J. Vaya, P. A. Belinky, and M. Aviram, “Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation,” Free Radical Biology and Medicine, vol. 23, no. 2, pp. 302–313, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Lata, S. Kakkar, V. K. Srivastava, K. K. Saxena, R. S. Saxena, and A. Kumar, “Comparative antipyretic activity of Ocimum sanctum, Glycyrrhiza glabra and aspirin in experimentally-induced pyrexia in rats,” Indian Journal of Pharmacology, vol. 31, no. 1, pp. 71–75, 1999. View at Google Scholar
  20. N. Wittschier, G. Faller, and A. Hensel, “Aqueous extracts and polysaccharides from Liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa,” Journal of Ethnopharmacology, vol. 125, no. 2, pp. 218–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Dong, A. Inoue, Y. Zhu, M. Tanji, and R. Kiyama, “Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root,” Food and Chemical Toxicology, vol. 45, no. 12, pp. 2470–2478, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. G. B. Zore, U. B. Winston, B. S. Surwase et al., “Chemoprofile and bioactivities of Taverniera cuneifolia (Roth) Arn.: a wild relative and possible substitute of Glycyrrhiza glabra L.,” Phytomedicine, vol. 15, no. 4, pp. 292–300, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. V. K. Gupta, A. Fatima, U. Faridi et al., “Antimicrobial potential ofGlycyrrhiza glabraroots,” Journal of Ethnopharmacology, vol. 116, no. 2, pp. 377–380, 2008. View at Google Scholar
  24. W. Larkworthy and P. F. Holgate, “Deglycyrrhizinized liquorice in the treatment of chronic duodenal ulcer. A retrospective endoscopic survey of 32 patients,” Practitioner, vol. 215, no. 1290, pp. 787–792, 1975. View at Google Scholar · View at Scopus
  25. A. Bennett, T. Clark-Wibberley, I. F. Stamford, and J. E. Wright, “Aspirin-induced gastric mucosal damage in rats: cimetidine and deglycyrrhizinated liquorice together give greater protection than low doses of either drug alone,” Journal of Pharmacy and Pharmacology, vol. 32, no. 2, p. 151, 1980. View at Google Scholar · View at Scopus
  26. R. A. Feldman, “Epidemiologic observations and open questions about disease and infection caused by Helicobacter pylori,” in Helicobacter pylori: Molecular and Cellular Biology, M. Achtman and S. Suerbaum, Eds., pp. 29–51, Horizon Scientific Press, Wymondham, UK, 2001. View at Google Scholar
  27. L. I. Zhang, G. E. Yan-li, Lin. Yong-hui, Wang. Zhi-rong, Wu. Qiong, and Zhang. Jun-jie, “Experimental study of the effect of Glycyrrhiza flavonoids on gastric cancer in vivo,” Journal of Tongji University, 2010. View at Google Scholar
  28. C. V. Chandrasekaran, K. Sundarajan, A. Gupta, H. S. Srikanth, J. Edwin, and A. Agarwal, “Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard),” Regulatory Toxicology and Pharmacology, vol. 61, no. 3, pp. 373–380, 2011. View at Google Scholar
  29. K. R. Raveendra, Jayachandra, and V. Srinivasa, “An extract of Glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 216970, 2012. View at Publisher · View at Google Scholar
  30. M. Mukherjee, N. Bhaskaran, R. Srinath et al., “Anti-ulcer and antioxidant activity of GutGard,” Indian Journal of Experimental Biology, vol. 48, no. 3, pp. 269–274, 2010. View at Google Scholar · View at Scopus
  31. G. van Belle and Steven P. Millard, STRUTS Statistical Rules of Thumb, University of Washington, Seattle, Wash, USA.
  32. L. Zhang, J. Ma, K. Pan, V. L. Go, J. Chen, and W. C. You, “Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial,” Helicobacter, vol. 10, no. 2, pp. 139–145, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Asaka, M. Kato, S. Takahashi et al., “Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition,” Helicobacter, vol. 15, no. 1, pp. 1–20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Iimuro, H. Shibata, T. Kawamori et al., “Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils,” Cancer Letters, vol. 187, no. 1-2, pp. 61–68, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Matsubara, H. Shibata, F. Ishikawa et al., “Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils,” Biochemical and Biophysical Research Communications, vol. 310, no. 3, pp. 715–719, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. F. Nariman, F. Eftekhar, Z. Habibi, and T. Falsafi, “Anti-Helicobacter pylori activities of six Iranian plants,” Helicobacter, vol. 9, no. 2, pp. 146–151, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Lengsfeld, F. Titgemeyer, G. Faller, and A. Hensel, “Glycosylated compounds from Okra inhibit adhesion of Helicobacter pylori to human gastric mucosa,” Journal of Agricultural and Food Chemistry, vol. 52, no. 6, pp. 1495–1503, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Fukai, A. Marumo, K. Kaitou, T. Kanda, S. Terada, and T. Nomura, “Anti-Helicobacter pylori flavonoids from licorice extract,” Life Sciences, vol. 71, no. 12, pp. 1449–1463, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Krausse, J. Bielenberg, W. Blaschek, and U. Ullmann, “In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites,” Journal of Antimicrobial Chemotherapy, vol. 54, no. 1, pp. 243–246, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. D. Kobayashi, Y. Eishi, T. Ohkusa et al., “Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading,” Journal of Medical Microbiology, vol. 51, no. 4, pp. 305–311, 2002. View at Google Scholar · View at Scopus
  41. V. De Francesco, A. Zullo, F. Perna et al., “Helicobacter pylori antibiotic resistance and [13C] urea breath test values,” Journal of Medical Microbiology, vol. 59, no. 5, pp. 588–591, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Perri, R. Clemente, M. Pastore et al., “The 13C-urea breath test as a predictor of intragastric bacterial load and severity of Helicobacter pylori gastritis,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 58, no. 1, pp. 19–27, 1998. View at Publisher · View at Google Scholar · View at Scopus
  43. R. M. Zagari, P. Pozzato, C. Martuzzi et al., “13C-urea breath test to assess Helicobacter pylori bacterial load,” Helicobacter, vol. 10, no. 6, pp. 615–619, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. F. Cremonini, F. Bartolozzi, A. Armuzzi et al., “Can 13C urea breath test predict resistance to therapy in Helicobacter pylori infection?” Hepato-Gastroenterology, vol. 52, no. 64, pp. 1119–1121, 2005. View at Google Scholar · View at Scopus
  45. A. Zullo, L. Sanchez-Mete, C. Hassan et al., “Helicobacter pylori density and cagA status in cirrhotic patients: a case-control study,” Journal of Gastroenterology and Hepatology, vol. 19, no. 10, pp. 1174–1178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. S. A. Sarker, S. Nahar, M. Rahman et al., “High prevalence of cagA and vacA seropositivity in asymptomatic Bangladeshi children with Helicobacter pylori infection,” Acta Paediatrica, vol. 93, no. 11, pp. 1432–1436, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Vaira, P. Malfertheiner, F. Mégraud et al., “Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay,” The Lancet, vol. 354, no. 9172, pp. 30–33, 1999. View at Publisher · View at Google Scholar · View at Scopus
  48. D. Vaira, P. Malfertheiner, F. Megraud et al., “Noninvasive antigen-based assay for assessing Helicobacter pylori eradication: a European multicenter study,” The American Journal of Gastroenterology, vol. 95, no. 4, pp. 925–929, 2000. View at Google Scholar
  49. D. Vaira, N. Vakil, M. Menegatti et al., “The stool antigen test for detection of Helicobacter pylori after eradication therapy,” Annals of Internal Medicine, vol. 136, no. 4, pp. 280–287, 2002. View at Google Scholar · View at Scopus
  50. E. Myllyluoma, L. Veijola, T. Ahlroos et al., “Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy: a placebo-controlled, double-blind randomized pilot study,” Alimentary Pharmacology and Therapeutics, vol. 21, no. 10, pp. 1263–1272, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. S. J. Lee, J. Y. Park, K. S. Choi et al., “Efficacy of Korean red ginseng supplementation on eradication rate and gastric volatile sulfur compound levels after Helicobacter pylori eradication therapy,” Journal of Ginseng Research, vol. 34, no. 2, pp. 122–131, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Jarosz, J. Dzieniszewski, E. Dabrowska-Ufniarz, M. Wartanowicz, S. Ziemlanski, and P. Reed, “Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice,” European Journal of Cancer Prevention, vol. 7, no. 6, pp. 449–454, 1998. View at Publisher · View at Google Scholar · View at Scopus
  53. E. M. Salem, T. Yar, A. O. Bamosa et al., “Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter pylori in patients with non-ulcer dyspepsia,” Saudi Journal of Gastroenterology, vol. 16, no. 3, pp. 207–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. W. L. Peterson, D. Y. Graham, B. Marshall et al., “Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial,” The American Journal of Gastroenterology, vol. 88, no. 11, pp. 1860–1864, 1993. View at Google Scholar
  55. Y. K. Joshi, “Helicobacter pylori infection: current status,” Journal of Indian Academy of Clinical Medicine, vol. 5, no. 2, pp. 148–155, 2000. View at Google Scholar
  56. S. P. Thyagarajan, P. Ray, B. K. Das et al., “Geographical difference in antimicrobial resistance pattern of H. pylori clinical isolates from Indian patients: multicentric study,” Journal of Gastroenterology and Hepatology, vol. 18, no. 12, pp. 1373–1378, 2003. View at Google Scholar
  57. R. Talaie, H. Zojaji, D. Mirsattari, A. Kaboli, A. H. M. Alizadeh, and M. R. Zali, “Comparison of two different eradication regimens for H. pylori: amoxicillin, metronidazole, bismuth and omeprazole (OMAB) versus the new regimen of penbactam, clarithromycin and omeprazole (OPC), a randomized clinical trial,” Journal of Gastroenterology and Hepatology, vol. 1, no. 3, pp. 19–22, 2008. View at Google Scholar
  58. S. Jang, K. R. Jones, C. H. Olsen et al., “Epidemiological link between gastric disease and polymorphisms in VacA and CagA,” Journal of Clinical Microbiology, vol. 48, no. 2, pp. 559–567, 2010. View at Google Scholar
  59. M. Chatterji, S. Unniraman, S. Mahadevan, and V. Nagaraja, “Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis,” Journal of Antimicrobial Chemotherapy, vol. 48, no. 4, pp. 479–485, 2001. View at Google Scholar · View at Scopus
  60. M. K. Asha, D. Debraj, D. Prashanth et al., “In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action,” Journal of Ethnopharmacology, vol. 145, no. 2, pp. 581–586, 2013. View at Google Scholar
  61. X. U. Hui, Y. A. O. Pan, L. I. N. Guodong, and C. H. E. N. Weiwen, “In-vitro inhibitory effect of methanol extracts of Chinese herbal drugs on supercoiling activity of bacterial DNA Gyrase [OL],” 2011, http://www.paper.edu.cn/index.php/default/en_releasepaper/content/4411791.
  62. G. L. Mendz, A. J. Shepley, S. L. Hazell, and M. A. Smith, “Purine metabolism and the microaerophily of Helicobacter pylori,” Archives of Microbiology, vol. 168, no. 6, pp. 448–456, 1997. View at Publisher · View at Google Scholar · View at Scopus