Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles

Table 3

In vitro leishmanicidal activity of isolated compounds on promastigotes of Leishmania amazonensis and L. brasiliensis.

Species	Isolated compounds	L. amazonensis IC50 (μg/mL)^a	L. brasiliensis IC50 (μg/mL)^a
A. schottii	Plumericin	0.3±0.07	0.04±0.007
	Plumieride	>100	21.3±2.80
	Ursolic acid	66.1±1.22	8.3±0.84
R. ferruginea	Myrsinoic acid B	24.1±0.52	6.1±0.24
E. umbelliflora	Eugenial A	>100	53.8±1.71
G. achachairu	Guttiferone A	10.4±0.50	18.4±0.20
S. sisymbriifolium	Cilistol A	6.6±0.22	3.1±0.25
	Cilistadiol	>100	59.8±0.32
Positive control	Catetanol	21.1±4.27	21.4±5.53
	Amphotericin B	0.6±0.36	0.7±0.36

aData are expressed as mean ± standard deviation of three determinations.