Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 265061, 12 pages
http://dx.doi.org/10.1155/2013/265061
Research Article

Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice

1Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
2Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
3Wenzhou Medical College, Wenzhou, Zhejiang 325035, China
4The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China

Received 29 March 2013; Accepted 26 April 2013

Academic Editor: Thomas Efferth

Copyright © 2013 Jian-Li Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. Lu, J. L. Bao, X. P. Chen, M. Huang, and Y. T. Wang, “Alkaloids isolated from natural herbs as the anticancer agents,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 485042, 12 pages, 2012. View at Publisher · View at Google Scholar
  2. L. W. Fu, Y. M. Zhang, Y. J. Liang, X. P. Yang, and Q. C. Pan, “The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells,” European Journal of Cancer, vol. 38, no. 3, pp. 418–426, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. T. H. Wang, J. Y. Wan, X. Gong, H. Z. Li, and Y. Cheng, “Tetrandrine enhances cytotoxicity of cisplatin in human drug-resistant esophageal squamous carcinoma cells by inhibition of multidrug resistance-associated protein 1,” Oncology Reports, vol. 28, no. 5, pp. 1681–1686, 2012. View at Publisher · View at Google Scholar
  4. Y. L. Lai, Y. J. Chen, T. Y. Wu et al., “Induction of apoptosis in human leukemic U937 cells by tetrandrine,” Anti-Cancer Drugs, vol. 9, no. 1, pp. 77–81, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Wu, Y. Chen, J. C. Chen, T. Y. Lin, and S. H. Tseng, “Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice,” Cancer Letters, vol. 287, no. 2, pp. 187–195, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Li, B. Su, R. Liu, D. Wu, and D. He, “Tetrandrine induces apoptosis and triggers caspase cascade in human bladder cancer cells,” Journal of Surgical Research, vol. 166, no. 1, pp. e45–e51, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. L. T. Ng, L. C. Chiang, Y. T. Lin, and C. C. Lin, “Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines,” American Journal of Chinese Medicine, vol. 34, no. 1, pp. 125–135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. H. Lee, G. H. Kang, K. C. Kim et al., “Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells,” International Journal of Oncology, vol. 21, no. 6, pp. 1239–1244, 2002. View at Google Scholar · View at Scopus
  9. B. C. He, J. L. Gao, B. Q. Zhang et al., “Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer,” Molecular Pharmacology, vol. 79, no. 2, pp. 211–219, 2011. View at Google Scholar
  10. Y. Chen, J. C. Chen, and S. H. Tseng, “Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats,” International Journal of Cancer, vol. 124, no. 10, pp. 2260–2269, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Huang, Y. Bi, W. Jiang et al., “Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential,” PLoS One, vol. 7, no. 2, Article ID e32428, 2012. View at Publisher · View at Google Scholar
  12. Y. Su, X. Luo, B. C. He et al., “Establishment and characterization of a new highly metastatic human osteosarcoma cell line,” Clinical and Experimental Metastasis, vol. 26, no. 7, pp. 599–610, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. L. Gao, T. C. He, Y. B. Li, and Y. T. Wang, “A traditional chinese medicine formulation consisting of Rhizoma corydalis and Rhizoma curcumae exerts synergistic anti-tumor activity,” Oncology Reports, vol. 22, no. 5, pp. 1077–1083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. B. C. He, J. L. Gao, X. Luo et al., “Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/β-catenin signaling,” International Journal of Oncology, vol. 38, no. 2, pp. 437–445, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. J. L. Gao, J. M. Shi, S. M. Y. Lee, Q. W. Zhang, and Y. T. Wang, “Angiogenic pathway inhibition of Corydalis yanhusuo and berberine in human umbilical vein endothelial cells,” Oncology Research, vol. 17, no. 11-12, pp. 519–526, 2009. View at Google Scholar · View at Scopus
  16. Y. W. Liu, J. L. Gao, J. Guan, Z. M. Qian, K. Feng, and S. P. Li, “Evaluation of antiproliferative activities and action mechanisms of extracts from two species of ganoderma on tumor cell lines,” Journal of Agricultural and Food Chemistry, vol. 57, no. 8, pp. 3087–3093, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. L. Gao, J. M. Shi, K. He et al., “Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways,” Oncology Reports, vol. 20, no. 4, pp. 819–824, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. S. A. DuPré, D. Redelman, and K. W. Hunter Jr., “The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci,” International Journal of Experimental Pathology, vol. 88, no. 5, pp. 351–360, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Stücker, M. Esser, M. Hoffmann et al., “High-resolution laser Doppler perfusion imaging aids in differentiating between benign and malignant melanocytic skin tumours,” Acta Dermato-Venereologica, vol. 82, no. 1, pp. 25–29, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Esser, E. Oosterink, J. op 't Roodt et al., “Vascular and inflammatory high fat meal responses in young healthy men, a discriminative role of IL-8 observed in a randomized trial,” PLoS One, vol. 8, no. 2, Article ID e53474, 2013. View at Publisher · View at Google Scholar
  21. L. Chen, W. Jiang, J. Huang et al., “Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation,” Journal of Bone and Mineral Research, vol. 25, no. 11, pp. 2447–2459, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. P. Fan, J. C. Yeh, K. W. Leung, P. Y. K. Yue, and R. N. S. Wong, “Angiogenesis: from plants to blood vessels,” Trends in Pharmacological Sciences, vol. 27, no. 6, pp. 297–309, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. K. H. Chang, H. F. Liao, H. H. Chang et al., “Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma-bearing BALB/c mice,” American Journal of Chinese Medicine, vol. 32, no. 6, pp. 863–872, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. P. L. Kuo and C. C. Lin, “Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells,” Life Sciences, vol. 73, no. 2, pp. 243–252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. L. H. Meng, H. Zhang, L. Hayward, H. Takemura, R. G. Shao, and Y. Pommier, “Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G 1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1,” Cancer Research, vol. 64, no. 24, pp. 9086–9092, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. A. McCubrey, J. Bäsecke, M. Cervello, A. M. Martelli, and R. A. Franklin, “GSK-3β is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity,” Cancer Biology and Therapy, vol. 7, no. 7, p. 1079, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. X. L. Chen, K. H. Ren, H. W. He, and R. G. Shao, “Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis,” Cancer Biology and Therapy, vol. 7, no. 7, pp. 1073–1078, 2008. View at Google Scholar
  28. C. Liu, K. Gong, X. Mao, and W. Li, “Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma,” International Journal of Cancer, vol. 129, no. 6, pp. 1519–1531, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. S. H. Oh and B. H. Lee, “Induction of apoptosis in human hepatoblastoma cells by tetrandrine via caspase-dependent Bid cleavage and cytochrome c release,” Biochemical Pharmacology, vol. 66, no. 5, pp. 725–731, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Stücker, C. Springer, V. Paech, N. Hermes, M. Hoffmann, and P. Altmeyer, “Increased laser Doppler flow in skin tumors corresponds to elevated vessel density and reactive hyperemia,” Skin Research and Technology, vol. 12, no. 1, pp. 1–6, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. G. L. Semenza, “HIF-1: mediator of physiological and pathophysiological responses to hypoxia,” Journal of Applied Physiology, vol. 88, no. 4, pp. 1474–1480, 2000. View at Google Scholar · View at Scopus
  32. S. A. Siefert and R. Sarkar, “Matrix metalloproteinases in vascular physiology and disease,” Vascular, vol. 20, no. 4, pp. 210–216, 2012. View at Google Scholar
  33. G. J. Mizejewski, “Role of integrins in cancer: survey of expression patterns,” Proceedings of the Society for Experimental Biology and Medicine, vol. 222, no. 2, pp. 124–138, 1999. View at Google Scholar · View at Scopus
  34. J. D. Hood and D. A. Cheresh, “Role of integrins in cell invasion and migration,” Nature Reviews Cancer, vol. 2, no. 2, pp. 91–100, 2002. View at Google Scholar · View at Scopus
  35. A. Bianchi-Smiraglia, S. Paesante, and A. V. Bakin, “Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways,” Oncogene, 2012. View at Publisher · View at Google Scholar
  36. Y. H. Kang, N. Y. Ji, S. R. Han et al., “ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer,” Cellular Signalling, vol. 24, no. 10, pp. 1940–1949, 2012. View at Publisher · View at Google Scholar
  37. Y. H. Kang, N. Y. Ji, C. I. Lee et al., “ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma,” Amino Acids, vol. 40, no. 3, pp. 1003–1013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Guo, Z. Zhou, Y. Dou, J. Tang, C. Gao, and J. Huan, “GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB,” Cytokine, vol. 57, no. 3, pp. 417–428, 2012. View at Google Scholar
  39. P. Melotti, E. Nicolis, A. Tamanini, R. Rolfini, A. Pavirani, and G. Cabrini, “Activation of NF-κB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector,” Gene Therapy, vol. 8, no. 18, pp. 1436–1442, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Y. Tung, S. F. Chang, M. H. Chou et al., “CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1,” Journal of Biomedical Science, vol. 19, article 91, 2012. View at Publisher · View at Google Scholar
  41. Y. Usami, K. Ishida, S. Sato et al., “Intercellular adhesion molecule-1 (ICAM-1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion,” International Journal of Cancer, 2013. View at Publisher · View at Google Scholar