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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 268963, 7 pages
http://dx.doi.org/10.1155/2013/268963
Review Article

Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial

Zhidong Wang,1,2,3 Jun Li,2,3 Yuanyuan Ji,2,3 Peng An,3 Shu Zhang,1,2,3 and Zongfang Li1,2,3

1Department of General Surgery, The Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an 710004, China
2National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Xi’an 710004, China
3Shaanxi Province Engineering Research Center of Biotherapy and Translation Medicine, Xi’an 710004, China

Received 28 March 2013; Revised 23 June 2013; Accepted 25 June 2013

Academic Editor: Sookyung Lee

Copyright © 2013 Zhidong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. W. Huang, Y. M. Tao, and X. Ding, “Endocan expression correlated with poor survival in human hepatocellular carcinoma,” Digestive Diseases and Sciences, vol. 54, no. 2, pp. 389–394, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Ni, X. G. Gong, M. Lu, H. M. Chen, and Y. Wang, “Mitochondrial ROS burst as an early sign in sarsasapogenin-induced apoptosis in HepG2 cells,” Cell Biology International, vol. 32, no. 3, pp. 337–343, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Maluccio and A. Covey, “Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma,” CA: A Cancer Journal For Clinicians, vol. 62, no. 6, pp. 394–399, 2012. View at Publisher · View at Google Scholar
  4. K. Zhu, Z. Dai, Q. Pan et al., “Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition,” Clinical Cancer Research, vol. 17, no. 23, pp. 7294–7302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Yang, X. Li, X. Li et al., “Traditional Chinese medicine in cancer care: a review of case series published in the Chinese literature,” Evidence Based Complementary and Alternative Medicine, vol. 2012, Article ID 751046, 8 pages, 2012. View at Publisher · View at Google Scholar
  6. X. Y. Huang, L. Wang, Z. L. Huang, Q. Zheng, Q. S. Li, and Z. Y. Tang, “Herbal extract Songyou Yin inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential,” Journal of Cancer Research and Clinical Oncology, vol. 135, no. 9, pp. 1245–1255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Xiong, Z. G. Ren, S. J. Qiu et al., “Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin,” BMC Cancer, vol. 10, article 219, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. A. Jia, Z. G. Ren, Y. Bu et al., “Herbal compound, “Songyou Yin” renders hepatocellular carcinoma sensitive to oxaliplatin through inhibition of stemness,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 908601, 12 pages, 2012. View at Publisher · View at Google Scholar
  9. X. Y. Huang, Z. L. Huang, L. Wang et al., “Herbal compound “Songyou Yin” reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice,” BMC Cancer, vol. 10, article 580, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Cao, W. Lin, Z. Huang et al., “Ethyl acetate extraction from a Chinese herbal formula, Jiedu Xiaozheng Yin, inhibits the proliferation of hepatocellular carcinoma cells via induction of G0/G1 phase arrest in vivo and in vitro,” International Journal of Oncology, vol. 42, no. 1, pp. 202–210, 2013. View at Publisher · View at Google Scholar
  11. Z. Cao, W. Lin, Z. Huang et al., “Jiedu Xiaozheng Yin, a Chinese herbal formula, inhibits tumor angiogenesis via downregulation of VEGF-A and VEGFR-2 expression in vivo and in vitro,” Oncology Reports, vol. 29, no. 3, pp. 1080–1086, 2013. View at Publisher · View at Google Scholar
  12. X. Li, Z. M. Shi, P. Feng, Z. Y. Wen, and X. J. Wang, “Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis,” World Journal of Gastroenterology, vol. 13, no. 31, pp. 4192–4198, 2007. View at Google Scholar · View at Scopus
  13. Z. Wen, Z. Shi, P. Feng, X. Xue, K. Dong, and X. Wang, “Modulation of energy metabolic enzyme expression in N-nitrosodiethylamine-mediated hepatocarcinogenesis by Chinese herbs, Huqi San,” BioFactors, vol. 34, no. 4, pp. 303–312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Zeng, X. Li, X. Xue et al., “Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan,” Experimental and Therapeutic Medicine, vol. 5, no. 3, pp. 695–700, 2013. View at Google Scholar
  15. Z. Y. Cao, X. Z. Chen, L. M. Liao et al., “Fuzheng Yiliu Granule inhibits the growth of hepatocellular cancer by regulating immune function and inducing apoptosis in vivo and in vitro.,” Chinese Journal of Integrative Medicine, vol. 17, no. 9, pp. 691–697, 2011. View at Google Scholar · View at Scopus
  16. K. Takayasu, “Transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: recent progression and perspective,” Oncology, vol. 84, supplement 1, pp. 28–33, 2013. View at Google Scholar
  17. Y. Yu, Q. Lang, Z. Chen et al., “The efficacy for unresectable hepatocellular carcinoma may be improved by transcatheter arterial chemoembolization in combination with a traditional Chinese herbal medicine formula: a retrospective study,” Cancer, vol. 115, no. 22, pp. 5132–5138, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Chen, H. Y. Chen, Q. B. Lang et al., “Preventive effects of jiedu granules combined with cinobufacini injection versus transcatheter arterial chemoembolization in post-surgical patients with hepatocellular carcinoma: a case-control trial,” Chinese Journal of Integrative Medicine, vol. 18, no. 5, pp. 339–344, 2012. View at Publisher · View at Google Scholar
  19. M. B. Meng, Q. L. Wen, Y. L. Cui, B. She, and R. M. Zhang, “Meta-analysis: traditional Chinese medicine for improving immune response in patients with unresectable hepatocellular carcinoma after transcatheter arterial chemoembolization,” Explore, vol. 7, no. 1, pp. 37–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Q. Tian, H. L. Li, B. Wang et al., “Treatment of middle/late stage primary hepatic carcinoma by Chinese medicine comprehensive therapy: a prospective randomized controlled study,” Chinese Journal of Integrative Medicine, vol. 16, no. 2, pp. 102–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. B. Meng, Y. L. Cui, Y. S. Guan et al., “Traditional Chinese medicine plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma,” Journal of Alternative and Complementary Medicine, vol. 14, no. 8, pp. 1027–1042, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. S. C. Tsai, J. S. Yang, S. F. Peng et al., “Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells,” International Journal of Oncology, vol. 41, no. 4, pp. 1431–1442, 2012. View at Publisher · View at Google Scholar
  23. Q. Miao, L. L. Bi, X. Li, and et. al, “Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy,” International Journal of Molecular Sciences, vol. 14, no. 1, pp. 1370–1382, 2013. View at Publisher · View at Google Scholar
  24. D. M. Zhang, J. S. Liu, L. J. Deng et al., “Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway,” Carcinogenesis, vol. 34, no. 6, pp. 1331–1342, 2013. View at Publisher · View at Google Scholar
  25. M. Li, S. Wu, Z. Liu et al., “Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway,” Biochemical Pharmacology, vol. 83, no. 9, pp. 1251–1260, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. Z. F. Li, Z. D. Wang, Y. Y. Ji et al., “Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract,” World Journal of Gastroenterology, vol. 15, no. 36, pp. 4538–4546, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Yuan, Z. Li, X. Li et al., “Distinct effect of Chrysanthemum indicum Linné extracts on isoproterenol-induced growth of human hepatocellular carcinoma cells,” Oncology Reports, vol. 22, no. 6, pp. 1357–1363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. D. Wang, C. Huang, Z. F. Li et al., “Chrysanthemum indicum ethanolic extract inhibits invasion of hepatocellular carcinoma via regulation of MMP/TIMP balance as therapeutic target,” Oncology Reports, vol. 23, no. 2, pp. 413–421, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. J. Dai, X. J. Wang, Z. F. Li et al., “Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3,” World Journal of Gastroenterology, vol. 14, no. 48, pp. 7321–7328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. J. Dai, J. Gao, Z. F. Li et al., “In vitro and in vivo antitumor activity of Scutellaria barbate extract on murine liver cancer,” Molecules, vol. 16, no. 6, pp. 4389–4400, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Dai, X. Liu, Z. Ji et al., “The effect-enhancing and toxicity-reducing action of the extract of Herba Scutellariae barbatae for chemotherapy in hepatoma H22 tumor-bearing mice,” Journal of Traditional Chinese Medicine, vol. 28, no. 3, pp. 205–210, 2008. View at Google Scholar · View at Scopus
  32. J. Q. Zhang, Y. M. Li, T. Liu et al., “Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy,” World Journal of Gastroenterology, vol. 16, no. 34, pp. 4281–4290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. R. R. Liang, S. Zhang, J. A. Qi et al., “Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling,” International Journal of Oncology, vol. 41, no. 3, pp. 969–978, 2012. View at Publisher · View at Google Scholar
  34. Y. P. Zhan, X. E. Huang, J. Cao et al., “Clinical safety and efficacy of Kanglaite (Coix Seed Oil) injection combined with chemotherapy in treating patients with gastric cancer,” Asian Pacific Jounal of Cancer Prevention, vol. 13, no. 10, pp. 5319–5321, 2012. View at Google Scholar
  35. X. F. Zhu, “The clinical observation of the effect of kanlaite injection combined with chemoembolization primary on middle and advanced stage liver cancer,” Jounal of Basic and Clinical Oncology, vol. 19, no. 2, pp. 132–134, 2006. View at Google Scholar
  36. X. H. Xu, J. Su, and X. Y. Fu, “Kanlaite effect of injection combination with capecitabin on patients with advanced stage HCC,” Li Shizhen Medicine and Materia Medica Research, vol. 21, no. 6, pp. 1479–1480, 2010. View at Google Scholar
  37. B. Wang, H. Q. Tian, and G. W. Liang, “Effect of ganji recipe combined with Fructus Bruceae oil emulsion intervention on quality of life in patients with advanced primary hepatic cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 29, no. 3, pp. 257–260, 2009. View at Google Scholar · View at Scopus
  38. M. Z. Yang, H. Wang, G. J. Jiang, K. F. Zhao, Z. Cai, and K. Zhao, “Interventional treatment for elderly advanced primary liver cancer by Brucea javanica Oil emulsion,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 17, no. 2, pp. 235–237, 2011. View at Google Scholar
  39. Y. H. Liao, C. C. Lin, T. C. Li, and J. G. Lin, “Utilization pattern of traditional Chinese medicine for liver cancer patients in Taiwan,” BMC Complementary and Alternative Medicine, vol. 2012, article 146, 2012. View at Publisher · View at Google Scholar
  40. X. Shu, M. McCulloch, H. Xiao, M. Broffman, and J. Gao, “Chinese herbal medicine and chemotherapy in the treatment of hepatocellular carcinoma: a meta-analysis of randomized controlled trials,” Integrative Cancer Therapies, vol. 4, no. 3, pp. 219–229, 2005. View at Publisher · View at Google Scholar · View at Scopus