Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

Figure 6

Graphical representation of main genes involved in signaling pathways, transcription regulation, cell growth, cell cycle, and apoptosis for which deregulation has been implicated in cancer development. Genes depicted in red color were upregulated and genes represented in green color were downregulated in the colon mucosa of rats following the consumption of urolithin A, (Larrosa et al. [29]). Analyses were carried out using the Canonical Pathways Analysis tool of Ingenuity Pathways Analysis (Ingenuity Systems, Redwood City, CA, USA).