A Small Molecule Swertisin from Enicostemma littorale Differentiates NIH3T3 Cells into Islet-Like Clusters and Restores Normoglycemia upon Transplantation in Diabetic Balb/c Mice

Figure 12

Glucose responsive insulin and C-peptide release assay. (a) represents glucose responsive insulin release from SFM, activin A and swertisin-mediated ILCC with increasing glucose and L-arginine concentration. Results are expressed as mean±SEM of three independent observations, 𝑁=3. (b) represents glucose responsive C-peptide release from SFM, SFM+ITS, activin A and swertisin-mediated ILCC. Results are expressed as mean±SEM of three independent observations, 𝑁=3.

(a)

(b)