The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the included studies.

Study	Number of authors	Trial date report	Sample; size	Followup; (day)	Baseline comparison	AE	Outcomes; measure	Treatment group dosage	Angina
Chen 2009	1	1	100	15	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Chen et al. 2011	3	1	100	10	0	0	SYM	GXN 20 mL/d + CG	Angina
Chen 2006	1	1	62	14	1	1	SYM, ECG	GXN 20 mL/d + CG	Angina
Cheng and Zang 2010	2	1	43	14	1	0	SYM	GXN 30 mL/d + CG	Unstable
Cheng et al. 2011	3	1	76	14	1	1	SYM, ECG	GXN 30 mL/d + CG	Angina
Dong XP 2009	1	0	100	1	0	0.5	SYM	GXN 20 mL/d	Angina
Fu and Meng 2011	2	0	47	10	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Fu et al. 2010	4	1	56	14	1	0	SYM, ECG	GXN 200 ml + CG + shenmaiyin 40 ml	Angina
Gao et al. 2005	3	1	60	14	1	1	SYM, ECG	GXN 20 mL/d	Angina
Gong et al. 2009	3	1	85	14	1	1	SYM, ECG	GXN 20 mL/d + xueshuantong 20 ml	Stable
He and Meng 2007	1	1	49	15	1	0	SYM	GXN 20 mL/d + CG	Unstable
He 2009	1	1	120	28	1	1	SYM, ECG	GXN 30 mL/d + atorvastatin 10 mg	Unstable
Hou and Gao 2009	2	1	128	14	1	1	SYM, ECG	GXN 20 mL/d + CG	Stable
Huang et al. 2011	4	0	120	7	1	1	SYM	GXN 20 mL/d + CG + xueshuantong 400 mg	Angina
Jiang et al. 2010	3	1	116	10	1	0	SYM, ECG	GXN 20 mL/d + CG	Unstable
Jiang 2009	1	1	68	20	1	1	SYM, ECG	GXN 20 mL/d	Angina
Jiang et al. 2010	5	0	56	7	0	1	SYM	GXN 30 mL/d	Angina
Kong 2009	1	0	100	14	1	1	SYM	GXN 30 mL/d + CG	Unstable
Lan et al. 2006	3	1	64	14	1	1	SYM	GXN 20 mL/d	Angina
Li and Jia 2011	2	1	200	14	1	0	SYM, ECG	GXN 30 mL/d + CG	Angina
Li and Lei 2005	2	1	156	14	0	1	SYM, ECG	GXN 20 mL/d + CG	Angina
Li et al. 2009	5	1	168	14	1	0	SYM	GXN 20 mL/d + CG	Angina
Li and Ran 2009	2	1	160	10	1	1	SYM	GXN 20 mL/d + CG	Angina
Li 2004	1	0	83	7	1	0	SYM, ECG	GXN 20 mL/d + CG	Unstable
Liang and Feng 2010	2	0	120	14	1	0	SYM, ECG	GXN 20 mL/d + CG	Unstable
Liu 2004	1	1	104	10	1	1	SYM	GXN 20 mL/d + CG	Unstable
Liu and Li 2007	2	1	88	12	0	1	SYM	GXN 20 mL/d + CG	Unstable
Liu 2005	1	1	80	30	1	0	SYM, ECG	GXN 20 mL/d + CG	Unstable
Liu 2011	1	1	152	28	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Lu et al. 2006	3	1	68	30	1	0	SYM	GXN 30 mL/d + CG	Angina
Ma and Peng 2008	2	1	120	14	1	0	SYM	GXN 30 mL/d + CG	Unstable
Nie and Chen 2007	2	1	60	14	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Qiao and Wu 2004	2	0	81	28	1	1	SYM, ECG	GXN 20 mL/d + CG	Stable
Song 2010	1	1	82	7	0	0.5	SYM	GXN 20 mL/d + CG + diltiazem 90 mg/d	Unstable
Su 2009	1	1	90	15	0	1	SYM, ECG	GXN 6 mL/d + CG	Angina
Sun 2010	1	1	90	14	1	0	SYM, ECG	GXN 30 mL/d + CG	Unstable
Sun et al. 2006	5	1	98	15	0	0	SYM	GXN 20 mL/d + CG	Angina
Tian and Wu 2006	2	1	62	14	1	1	SYM	GXN 30 mL/d + CG	Unstable
Wan and Xu 2009	2	0	120	14	1	1	SYM, ECG	GXN 30 mL/d + CG	Unstable
Wang 2007	1	1	100	14	1	1	SYM, ECG	GXN 30 mL/d + CG	Angina
Wang 2011	1	1	85	14	1	1	SYM, ECG	GXN 20 mL/d + CG	Unstable
Wang 2011	2	1	112	14	1	1	SYM, ECG	GXN 20 mL/d + CG	Unstable
Wang and Ji 2008	2	1	60	14	0	0	SYM, ECG	GXN 20 mL/d + CG	Unstable
Wang and Sun 2007	2	1	92	10	0	0	SYM	GXN 20 mL/d + CG	Unstable
Wang 2005	2	1	60	15	1	0	SYM	GXN 20 mL/d + CG	Unstable
Wang 2010	1	0	80	14	1	1	SYM, ECG	GXN 20 mL/d + CG	Stable
Wang 2005	1	0	76	15	0	0	SYM	GXN 20 mL/d + CG + shenmai 30 mL/d + tongxinluo 9 pills/d	Unstable
Wang 2005	1	1	60	14	1	1	SYM	GXN 20 mL/d + CG	Unstable
Wang et al. 2011	4	1	60	14	1	1	SYM	GXN 20 mL/d + CG	Unstable
Wu et al. 2008	3	0	108	14	1	0	SYM	GXN 20 mL/d + CG	Angina
Wu et al. 2011	4	1	144	7	1	0	SYM	GXN 20 mL/d + CG + shenmai 50 mL/d	Unstable
Xia 2011	1	1	90	14	1	0	SYM, ECG	GXN 30 mL/d + CG	Unstable
Yang and Ma 2008	2	1	90	14	1	0	SYM, ECG	GXN 30 mL/d + CG	Unstable
Ye et al. 2008	3	0	76	15	0	1	SYM	GXN 20 mL/d + CG	Unstable
Yu and Wang 2009	2	1	75	15	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Yuan 2005	1	0	104	14	1	0	SYM, ECG	GXN 20 mL/d + CG	Angina
Zhang 2005	1	1	60	14	1	0	SYM, ECG	GXN 10 mL/d	Angina
Zhang 2010	1	1	240	15	1	1	SYM, ECG	GXN 20 mL/d + CG	Unstable
Zhang 2004	1	1	102	14	1	1	SYM, ECG	GXN 10 mL/d + CG + ginkgo leaf injection 10 mL/d	Angina
Zhang 2004	1	1	42	7	0	1	SYM	GXN 20 mL/d + CG	Angina
Zhao et al. 2010	6	1	100	14	1	1	SYM, ECG	GXN 10 mL/d + CG + xueshuangtong 120 mg	Unstable
Zhao and An 2008	2	1	90	28	1	1	SYM, ECG	GXN 20 mL/d + CG + simvastatin 10–20 mg/d	Unstable
Zhao 2010	1	1	86	14	1	0	SYM, ECG	GXN 30 mL/d + CG	Angina
Zhong et al. 2007	8	1	60	10	0	0	SYM	GXN 20 mL/d + CG	Angina
Zhu 2005	1	1	80	15	0	0.5	SYM, ECG	GXN 20 mL/d + CG	Unstable

GXN is Guanxinning injection; LMWH is low molecular weight heparin; and shenmai is Shenmai injection. CG is interventions of control group; SYM is SYMPTOMS; ECG is electrocardiogram; and AE is adverse event. The column of “Trial date report” shows that study did (1) or did not (0) report the trial date. The column of “Baseline comparison” shows that the study did (1) or did not (0) report the baseline comparison between the treatment and control groups.