The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 3

Subgroups and sensitivity analysis on SYMPTOMS outcomes.

	Group	Number of; RCTs	Number of; participants	OR	Wilcoxon; test	95% CI	Z	P (eff)	𝐼^2	𝜒^2	P (het)
M score	≤3	40	3625	3.21	W = 546	2.36, 4.35	7.46	<0.0001	54%	0.50	<0.0001
	>3	25	2439	3.51	P = 0.5395	2.78, 4.43	10.50	<0.0001	0%	0	0.9858
Sample size	<93	39	2772	3.22	W = 445.5	2.59, 4.01	10.51	<0.0001	0%	0	0.6150
	≥93	26	3292	3.37	P = 0.4140	2.39, 4.76	6.89	<0.0001	60%	0.47	<0.0001
Number of authors	1	27	2485	3.18	W = 1189	2.39, 4.24	7.92	<0.0001	28%	0.16	0.1253
	>1	38	3579	3.40	P = 0.7558	2.60, 4.46	8.87	<0.0001	44%	0.30	0.0031
Publication year	≤2008	31	2495	3.80	W = 441.5	3.01, 4.81	11.19	<0.0001	1%	0.01	0.2929
	>2008	34	3569	2.94	P = 0.2642	2.20, 3.93	7.32	<0.0001	48%	0.34	0.0016
Trial date report	Reported	51	4793	3.19	W = 2112.5	2.57, 3.95	10.52	<0.0001	36%	0.21	0.0189
	Not reported	14	1271	3.84	P = 1	2.33, 6.33	5.28	<0.0001	47%	0.40	0.0254
Baseline; comparison	Reported	50	4808	3.56	W = 2112.5	2.84, 4.45	11.10	<0.0001	40%	0.25	0.0057
	Not reported	15	1256	2.53	P = 1	1.75, 3.68	4.89	<0.0001	14%	0.08	0.1545
Adverse; events	Reported	31	2947	3.20	W = 1006	2.58, 3.97	10.59	<0.0001	0%	0	0.4304
	Not reported	34	3117	3.48	P = 0.4678	2.53, 4.78	7.68	<0.0001	51%	0.44	0.0003
Follow-up; period (day)	≤14	48	4461	3.38	W = 440	2.75, 4.16	11.51	<0.0001	28%	0.14	0.1321
	>14	17	1603	3.05	P = 0.6382	1.81, 5.16	4.18	<0.0001	61%	0.71	0.0005
GXN daily	6–200 mL	65	6064	3.32	W = 2059	2.72, 4.04	11.93	<0.0001	37%	0.23	0.0030
Dosage (mL)	6–30 mL	64	6008	3.34	P = 0.9231	2.73, 4.07	11.83	<0.0001	38%	0.24	0.0025
GXN daily	<20	4	352	3.42	𝜒^2 = 0.4290	1.48, 7.91	2.88	0.0040	38%	0.28	0.1717
Dosage (mL)	20	45	4235	3.16	df = 2	2.45, 4.07	8.85	<0.0001	46%	0.33	0.0004
	>20	16	1477	3.87	P = 0.8069	2.84, 5.29	8.51	<0.0001	0%	0	0.8315
Types of angina	Stable	4	374	3.42	𝜒^2 = 0.9900	1.89, 6.21	4.05	<0.0001	0%	0	0.7151
	Unstable	31	2892	3.07	df = 2	2.26, 4.16	7.18	<0.0001	47%	0.34	0.0013
	Angina	30	2798	3.61	P = 0.6096	2.72, 4.81	8.81	<0.0001	32%	0.19	0.1179
Improvement	>50%	65	6064	3.32	W = 02.5	2.72, 4.04	11.93	<0.0001	37%	0.23	0.0030
	>80%	63	5856	1.75	P < 0.0001	1.54, 1.98	8.65	<0.0001	25%	0.06	0.0557
GXN	1	6	408	3.19	𝜒^2 = 0.4891	1.86, 5.49	4.21	<0.0001	0%	0	0.8454
GXN + CG	2	49	4681	3.43	df = 2	2.81, 4.19	12.07	<0.0001	21%	0.11	0.1177
GXN + CG + additional	3	10	975	3.07	P = 0.7830	1.47, 6.41	2.99	0.00228	72%	0.98	<0.0001

CI is confidence interval; Z and P (eff) are statistical terms for evaluating overall effect; 𝐼², 𝜒², and P (het) are statistical terms for assessing heterogeneity among studies.