Rhodiola crenulata and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKCξ Pathway

Figure 5

RCE confers a similar preventive effect on the hypoxia-mediated reduction of Na,K-ATPase via a similar mechanism in a hypobaric rodent model. The rats were exposed to simulated hypobaric hypoxia (8000 m) for 9 h in the presence or absence of RCE. The expression of α1-Na,K-ATPase and PKCζ in the PM isolated from the right upper lobe of the lung (a) and the relative levels of α1-Na,K-ATPase (b) and PKCζ (c) were quantified. The expression of α1-Na,K-ATPase and p-AMPK in the PPM (d) and the relative levels of α1-Na,K-ATPase (e) and p-AMPK (f) were quantified. The results represent the mean ± SEM of four independent experiments. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001 versus control; ^#𝑃<0.05; ^#𝑃<0.01; ^###𝑃<0.001 versus hypoxia (H).

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