<i>Rhodiola crenulata</i> and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKC<i>ξ</i> Pathway

<table>The proposed mechanism of <i>Rhodiola crenulata</i> in attenuating the hypoxia-mediated Na,K-ATPase endocytosis. RCE and its bioactive components attenuate the hypoxia-induced <i>α</i>1-Na,K-ATPase endocytosis by inhibiting the ROS-AMPK-PKC<i>ζ</i> pathway.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 6

Figure 6: <i>Rhodiola crenulata</i> and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKC<i>ξ</i> Pathway 

Figure 6 | Rhodiola crenulata and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKCξ Pathway 