Research Article

Cytotoxicity and Modes of Action of the Methanol Extracts of Six Cameroonian Medicinal Plants against Multidrug-Resistant Tumor Cells

Table 1

Pharmacognosy of Cameroonian medicinal plants.

Samples, family, and herbarium numberaTraditional treatmentPart used in this study and extraction yield (%)bArea of plant collectionKnown bioactive (or potentially active) compoundsScreened activity for crude plant extract

Allanblackia gabonensis Pellegr. (Clusiaceae); 17275 SRF/CamDysentery, cold, toothache [19, 20]; pain, rheumatism, inflammations [21], cancer (personal information)Fruits (4.14%), leaves (10.16%), stem (8.42%) and roots bark (8.69%)Lebialem, South West region of CameroonAllan Xanthones A and D; 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone [22]Antimicrobial against Gram-positive and Gram-negative bacteria, yeasts, and mycelial fungus [22]; analgesic and anti-inflammatory effect of aqueous extract of the stem bark [21].
Anonidium mannii (oliv) Engl. et Diels.
(Annonaceae); 1918/SRFK
Sore feet, spider bite, bronchitis, dysentery, sterility caused by poison, gastroenteritis [23]; syphilis, infectious diseases [24]; diarrhea, snake bite, malaria [25], cancer (personal information)Leaves (3.39%)Bafoussam, West region of CameroonNot reportedNot reported
Gladiolus quartinianus A. Rich (Iridaceae); 17260/SRF/CamGastrointestinal infection, cancer (personal information)Whole plant (10.22%)Lebialem, South West region of CameroonNot reportedNot reported
Peperomia fernandopoiana C.DC.
(Piperaceae); 7171 SRF/Cam
Gastrointestinal infection, cancer (personal information)Whole plant (7.28%)Lebialem, South West region of CameroonNot reportedNot reported
Recinodindron heudelotii (Baill.) ex Pax. (Euphorbiaceae); 19695 SRF/CamCough, antidote, intestinal diseases, dysentery [2628]; malaria, anaemia, stomach pain, easy delivery, yellow fever, aphrodisiac [29], cancer (personal information)
Leaves (5.18%) and stems bark (5.72%)Melon, littoral region of CameroonE-ferulic acid octacosylate, 3-methylmethylorsellinate, lupeol, heudoletinone, 1,2-dihydroheudoleunol [26], aleuritolic acid 1 and labda-8(17),13-dien 3β,15-diol 2 [30] Antimicrobial activity of the stem bark against Streptococcus faecalis [30], Staphylococcus aureus, Bacillus cereus, Escherichia coli, Shigella dysenteriae, Shigella flexneri, Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans [31], antioxidant [32].
Vepris soyauxii Engl. (Rutaceae); 18394 SFR/CamAntifibromyoma, stomachache, malaria [32], cancer (personal information)Leaves (10.16%), stems (5.18%), and roots bark (9.26%)Melon, littoral region of CameroonNot reportedNot reported

Plants were identified at the Cameroon National Herbarium (HNC); The percentage of the methanol extract.