Cytotoxicity and Modes of Action of the Methanol Extracts of Six Cameroonian Medicinal Plants against Multidrug-Resistant Tumor Cells

Table 3

Cytotoxicity of the studied extracts towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay.

Cell lines	Studied samples, IC50 values (µg/mL)^a and degree of resistance (in bracket)
	Gladiolus quartinianus (Whole plant)	Vepris soyauxii (Leaves)	Anonidium mannii (Leaves)	Doxorubicin
CCRF-CEM	10.57±2.08	9.28±1.01	17.32±2.27	0.11±0.01
CEM/ADR5000	26.14±1.97 (2.47)	11.72±1.43 (1.26)	16.44±1.76 (0.95)	195.12±14.30 (1772)
MDA-MB-231	16.11±1.62	7.52±0.84	12.65±1.49	1.10±0.01
MDA-MB-231-BCRP	29.6±3.19 (1.49)	12.93±1.69 (1.71)	32.02±3.16 (2.53)	7.83±0.01 (7.11)
HCT116 𝑝53^+/+	19.83±1.66	8.59±0.88	13.61±1.79	1.43±0.02
HCT116 𝑝53^−/−	22.15±1.97 (1.12)	9.70±0.72 (1.12)	* (>2.94)	4.06±0.04 (2.84)
U87MG	*	8.75±1.21	22.25±2.76	1.06±0.03
U87MGΔEGFR	34.01±2.78 (<0.85)	4.09±0.56 (0.47)	9.14±1.77 (0.41)	6.11±0.04 (5.76)
HepG2	* (n.a)	13.60±1.22 (<0.34)	22.09±2.42 (0.55)	1.41±0.12 (<0.04)
AML12	*	*	*	*

aThe degree of resistance was determined as the ratio of IC₅₀ value of the resistant/IC₅₀ sensitive cell line.
(*): >40 µg/mL; n.a: not applicable.