Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 4

Research Article

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

Figure 4

VK2 induced caspase activation in prostate cancer cell lines. A NIR-FLIVO 747 In Vivo Apoptosis Tracer, which is a cell-permeable fluorescent detector of active caspases, was employed to determine whether 100 μM of VK2 activates caspase in prostate cancer cells. The LNCaP, 22RV1, and DU145 cell lines were treated with VK2 and then tested for caspase activation. Results showed that VK2 induced global caspase activation in LNCaP, 22RV1, and DU145 cells as early as 48 hours. * compared to control cells. Experiments were repeated four times and similar results were obtained.

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