Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells
Figure 9
VK2 inhibits hemoglobin levels in matrigel plugs implanted with prostate cancer cells. Angiogenic factors, including inducers and inhibitors, can be added to the matrigel matrix prior to the injection of human DU145 and 22Rv1 cells into nude mice. Matrigel, DU145 or 22RV1 cells and 100 μM of VK2 or the equivalent volume of sterile water were injected into the flanks of nude mice. After a period of 14 days, the gel matrix was recovered and angiogenesis of the recovered matrix gel was quantified using the hemoglobin assay. The hemoglobin level was considerably reduced in the VK2 treated DU145 ((a), (c) and (e)) and 22Rv1 cells ((b), (d), and (f)) () as compared to untreated control. The results are presented as a bar graph. The results shown here are representative of three independent results.
