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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 293010, 15 pages
http://dx.doi.org/10.1155/2013/293010
Research Article

A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism

1Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
2Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100029, China
3Beijing University of Chinese Medicine, Beijing 100029, China

Received 10 January 2013; Revised 1 March 2013; Accepted 1 March 2013

Academic Editor: Zhaoxiang Bian

Copyright © 2013 Wen Dai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prompt and accurate diagnosis of acute ischemic stroke is critical to seek acute therapy. In traditional Chinese medicine (TCM) science, there is a comprehensive system of diagnosis and medical care of acute ischemic stroke. Here we introduce a two-level model for the analysis of TCM syndrome of acute ischemic stroke. Owing to the limitation of sample size and imbalance, we focused on the analysis of wind-phlegm collateral obstruction syndrome (Feng Tan Yu Zu Zheng). Firstly, a Support-Vector-Machine- (SVM-) based diagnostic model was set up through selection of core symptoms. After pairwise undersampling, we improved the performance of prediction and generated the core symptoms-based diagnostic model of wind-phlegm collateral obstruction syndrome. Next, Pathway Pattern-based method and MetaDrug platform were used to shed light on the molecular basis of the significance of core symptoms in three complementary aspects: symptom-gene-pathway multilayer correlation network, enriched pathways, and most relevant interaction network. The integration of diagnostic model and molecular mechanism analysis creates an interesting perspective for better understanding the syndrome. The two-level model would provide a new opportunity for the study of TCM syndromes.