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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 296082, 17 pages
Research Article

Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism

1Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
2Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan
3Graduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung 402, Taiwan
4The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan
5Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
6Taiwan Leader Biotech Company, Taipei 24747, Taiwan
7Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung 40402, Taiwan
8Department of Biotechnology, Asia University, Taichung 41354, Taiwan
9Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

Received 14 June 2013; Accepted 6 October 2013

Academic Editor: Yew-Min Tzeng

Copyright © 2013 M. Gokila Vani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Additional information on this article including, list of antibodies and oligonucleotides were summarized in Table S1 and Table S2, respectively. Figure S1 (a and b) shows effect of cell viability on AAPH and antcin C. Figure S2 shows (a) Nrf2 knock-down by siNrf2 and (b) treatment with NAC or antcin C failed to prevent AAPH-induced cell death in Nrf2 knock-down cells. Figure S3 shows NAC treatment prevents AAPH-induced caspase-4 activation as well as cell death in hepatic cells. These data can be found in online appendix at

  1. Supplementary Materials
  2. Supplementary Materials