Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism

Table 2

Effect of antcin C on hepatic enzyme leakage, lipid peroxidation and glutathione depletion in AAPH-challenged mouse serum or liver tissues.

Parameters			AAPH (80 mg/Kg b.w)
			Antcin (mg/Kg b.w)			Silymarin (mg/Kg b.w)
	Control		25	50	100	200
Serum ALT (U/L)	4.1±0.2	6.2±2.3^†	4.9±1.4^∗∗	4.6±0.1^∗∗∗	4.2±0.1^∗∗∗	4.4±0.2^∗∗∗
Serum AST (U/L)	3.7±0.2	4.2±0.5^†	4.1±0.7^∗	3.7±0.2^∗∗∗	3.4±0.2^∗∗∗	3.6±0.1^∗∗∗
Hepatic GSH (mM)	97.2±2.7	54.3±9.9^†	90.9±7.9^∗∗	125.6±8.4^∗∗∗	162.3±18.8^∗∗∗	216.5±38.2^∗∗∗
Serum GSH (mM)	7.5±2.6	7.9±7.3	21.1±7.2^∗∗	49.9±8.0^∗∗∗	92.6±2.1^∗∗∗	81.9±1.5^∗∗∗
Hepatic MDA (mM)	6.2±1.1	20.9±1.2^†	13.3±1.1^∗	10.7±1.2^∗∗	6.4±1.2^∗∗∗	6.6±1.3^∗∗∗

Values represent the mean ± SD of three independent experiments. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 were considered significant for sample versus. AAPH. ^†𝑃<0.05 was considered significant for control versus AAPH.