High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects
Table 3
Body weight, liver index, spleen index, hydroxyproline level, GOT level and GTP level in the normal control group, 2-week DMN-treated group, and 4-week DMN-treated group.
Treatment†
Normal control
DMN-induced fibrosis (2 wk)
DMN-induced fibrosis (4 wk)/PBS (2 wk)
DMN-induced fibrosis (4 wk)/YGJ (2 wk)
Body weight (g)
471.3 ± 42.9
411.3 ± 34.7*
341.7 ± 40.4**
418.7 ± 36.9*,#
Liver index (%)
4.2 ± 0.3
4.1 ± 0.4
3.5 ± 0.7**
4.3 ± 0.8##
Spleen index (%)
0.2 ± 0.0
0.5 ± 0.1**
0.4 ± 0.1*
0.4 ± 0.1*
Hydroxyproline (µg/g liver)
208.7 ± 19.5
452.2 ± 67.8**
1187.1 ± 220.1***
403.5 ± 61.3*,##
GOT (U/L)
57.2 ± 1.7
175 ± 22.4***
136.8 ± 6.4**
71.9 ± 8.3*,#
GPT (U/L)
39.0 ± 7.1
83.4 ± 11.0**
97.8 ± 10.5**
52.0 ± 7.7*,#
Each value represents the mean ± SEM of five rats. < 0.05, **P < 0.01, ***P < 0.001 versus normal control.
#P < 0.05, ##P < 0.01 versus DMN-induced fibrosis/PBS group.
