Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet
The hepatic mRNA levels of SREBP-1c and its lipogenic target genes (a), PPARα and its target genes responsible for fatty acid β-oxidation (b), and inflammatory cytokines (c) in RCD- or HFD-fed hamsters receiving 8-week treatment with zerumbone (300 mg kg−1 per day, HFD-zerumbone) or lipanthyl (100 mg kg−1 per day, HFD-lipanthyl). The mRNA expressions of the lipogenic genes were measured by RT-PCR and normalized to an internal control (β-actin). Animals not receiving any treatment were given the same volume of vehicle used to dissolve zerumbone. Similar results were obtained with an additional 4 replications. Data were expressed as the mean with SD ( per group) in each column. and compared to the values of vehicle-treated RCD-fed hamsters (RCD-vehicle). and compared to the values of vehicle-treated HFD-fed hamsters (HFD-vehicle).
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