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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 309262, 6 pages
Research Article

Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB

1Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2Monash University, Department of Biochemistry and Molecular Biology, Clayton, Victoria 3800, Australia
3Visiting Professor, West China Hospital, Sichuan University, Chengdu 610041, China

Received 9 September 2013; Accepted 13 November 2013

Academic Editor: David Mischoulon

Copyright © 2013 Yi Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study explores the therapeutic effects of Xiangshao granules in a mouse depression model and examines the potential molecular mechanisms involved. After 21 consecutive days of chronic stress challenge, all mice were divided into three groups: control group, depression group, and Xiangshao granule treatment group. On the 22nd day, rats in the Xiangshao granule treatment group received Xiangshao granules via gastrogavage for 3 consecutive weeks. Depression group mice showed a significant reduction of crossings ( ) but not rearings ( ). Serum CRH, CORT, and ACTH levels were significantly increased in depression mice compared with control ( ) and the expression levels of hippocampal BDNF and TrkB were reduced in the model group ( ). However, Xiangshao granule treatment remarkably rescued the decrease in the body weight ( ), increased crossings in the open field test ( ), upregulated the expression of hippocampal BDNF and TrkB expression, and reduced the serum CRH, CORT, and ACTH concentrations compared with the depression group ( ). Collectively, these results demonstrated that Xiangshao granule could effectively induce antidepressive effects in the depression mouse model by ameliorating the expression of hippocampal BDNF and TrkB.