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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 313142, 5 pages
Research Article

Grape Seed Procyanidins in Pre- and Mild Hypertension: A Registry Study

Department of Biomedical Sciences, Irvine3 Circulation-Vascular Labs and San Valentino Vascular Screening Project, Gabriele D’Annunzio University, SS 16 Bis 94, Spoltore, Pescara, Italy

Received 22 July 2013; Accepted 20 August 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Gianni Belcaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The efficacy of a standardized grape seed procyanidins extract (GSPE, Enovita) to decrease blood pressure when associated with nondrug intervention (diet and lifestyle modifications) was investigated in a controlled registry study involving 119 healthy, pre- and mildly hypertensive subjects. Two dosages of Enovita were evaluated (150 and 300 mg/die), using blood pressure and heart rate as the primary endpoints and complementing these observations with a laser Doppler flowmetry (LDF) investigation of the microcirculation state and an evaluation of the plasma oxidative status. After four months of treatment, a statistically significant higher, and dose-dependent, improvement in all endpoints was observed in the treatment groups compared to that of the control, with blood pressure normalizing in 93% of the higher dosage (300 mg) treatment group. Taken together, these observations suggest that GSPEs have beneficial cardiovascular effects that complement current intervention strategies in the hypertension area. The effect on blood pressure adds to the beneficial effects of GSPEs on the cardiovascular disease (CVD) phenotype associated with the oxidation of membrane lipids (endothelial dysfunction, formation of oxidized LDL, and activation of phagocytic cells).