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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 319703, 6 pages
http://dx.doi.org/10.1155/2013/319703
Review Article

Ten Years’ Research on a Cardiovascular Tonic: A Comprehensive Approach—From Quality Control and Mechanisms of Action to Clinical Trial

1Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
2State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Hong Kong
3School of Medical Sciences, The Chinese University of Hong Kong, Hong Kong
4Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
5School of Life Sciences, The Chinese University of Hong Kong, Hong Kong
6School of Life Sciences, Biochemistry Programme, The Chinese University of Hong Kong, Hong Kong

Received 19 March 2013; Revised 21 August 2013; Accepted 19 September 2013

Academic Editor: Ka Kit Hui

Copyright © 2013 Ping-Chung Leung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Mortality arising from cardiovascular pathologies remains one of the highest. Maintenance of cardiovascular health therefore remains a universal concern. Interventional therapies and medications have made impressive advances, but preventive measures would be of the same importance. Method. Ten years’ search for a simple herbal formula has resulted in a two-herb combination, consisting of Salviae Miltiorrhizae Radix et Rhizoma and Puerariae Lobatae Radix. The formula has been studied extensively on cardiovascular biological platforms and then put on three clinical trials. Results. In the laboratory, the formula was found to have the biological effects of anti-inflammation, anti-oxidation, anti-foam cell formation on vascular endothelium, and vasodilation. Clinical trials using ultrasonic carotid intima thickness as a surrogate marker showed very significant benefits. No significant adverse effects were encountered. Conclusion. It is therefore recommended that the herbal formula could be used as an adjuvant therapy in cardiac patients under treatment or as a preventive agent among the susceptible.