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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 327629, 8 pages
http://dx.doi.org/10.1155/2013/327629
Research Article

The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes

1Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China
2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
3Department of Endocrinology, Peking Union Medical College Hospital, China Academy of Medical Sciences, Beijing 100730, China
4Department of Endocrinology, Peking University Third Hospital, Peking University, Beijing 100083, China
5Department of Endocrinology, Yiling Hospital, Yichang, Hubei 443100, China
6Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
7Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
8Department of Endocrinology, First People's Hospital of Hegang, Hegang, Heilongjiang 154100, China

Received 6 January 2013; Revised 25 March 2013; Accepted 25 March 2013

Academic Editor: William C. Cho

Copyright © 2013 Xi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications. However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment. A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study. DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation. Multinomial logistic regression analysis indicated that rs1142345 ( ) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug ( , FDR ). The “G” allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively. Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups ( , ) and between the healthy and deterioration groups ( , ). Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs. Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D.