The Ethanol Extract of Zingiber zerumbet Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats

Table 3

Effects of different treatments on kidney weight and kidney hypertrophy index (KI) in rats at the end of the eight-week treatment.

Groups	Kidney weight (g)	KI (mg g^−1)
Normal + vehicle	1.3 ± 0.2^d	3.8 ± 1.2^d
STZ + vehicle	2.7 ± 0.2^b	12.2 ± 3.6^b
STZ + EEZZR 200	2.2 ± 0.4^b	8.3 ± 2.8
STZ + EEZZR 300	2.2 ± 0.3^b	7.2 ± 1.9^a
STZ + Met	1.8 ± 0.4^c	5.5 ± 1.7^c

STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 100 mg kg⁻¹ per day metformin (STZ + Met), 200 mg kg⁻¹ per day EEZZR (STZ + EEZZR 200), or 300 mg kg⁻¹ EEZZR (STZ + EEZZR 300). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to dissolve the test medications. Values (mean ± SD) were obtained for each group of 8 animals. aP < .05 and bP < .01 compared to the values of vehicle-treated normal rats (normal + vehicle). cP < .05 and dP < .01 compared to the values of vehicle-treated STZ-diabetic rats (STZ + vehicle), respectively.