Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 3

Genes identified by standard or reverse COMPARE analyses, whose mRNA expression in a panel of 60 cell lines correlated with IC₅₀ values for hopeaphenol.

Pearson’s correlation coefficient	Experimental ID	Gene symbol	Name	Function
0.552	GC63503	HMGN4	High mobility group nucleosomal binding domain 4	Binds nucleosomal DNA
0.527	GC190712	UAP1	UDP-N-acetylglucosamine pyrophosphorylase 1	Nucleotidyltransferase
0.521	GC45602	TBC1D2	TBC1 domain family, member 2	GTPase activator
0.521	GC188142	ERBB2IP	Erbb2 interacting protein	Receptor adapter, structural constituent of cytoskeleton
0.515	GC26884	PRPS1	Phosphoribosyl pyrophosphate synthetase 1	Involved in nucleotide synthesis
0.513	GC38343	CNNTAL1		Unknown
−0.591	GC97260	MANBA	Mannosidase, beta A, lysosomal	Exoglycosidase
−0.574	GC73531	FGF9	Fibroblast growth factor 9 (glia-activating factor)	Cell growth and differentiation during development
−0.534	GC55495	CYP7B1	Cytochrome P450, family 7, subfamily B, polypeptide 1	Monooxygenase
−0.516	GC94617	GABRA3	Gamma-aminobutyric acid (GABA) A receptor, alpha 3	Neurotransmission
−0.515	GC184017	HES1	Hairy and enhancer of split 1, (Drosophila)	Transcriptional repressor

Information on gene functions was taken from the OMIM database, NCI, USA, (http://www.ncbi.nlm.nih.gov/Omim/) and from the GeneCard database of the Weizmann Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).