Research Article

Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress

Table 1

Time and length of stressors used in the CMS procedure. These stressors which were applied continuously, were randomly scheduled over a 1-week period and repeated throughout the 5-week period. At the same time, animals were treated with nobiletin (20 and 40 mg/kg, P.O.), fluoxetine (10 mg/kg, P.O.), or saline.

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Food and water deprivation16:00 10:0008:00–20:00
Stroboscopic illumination12:00–20:0020:00 08:00
White noise20:00 08:0008:00–20:00
Light/dark succession every 2 h08:00–20:0008:00–20:00
Overnight illumination20:00 08:00
45° cage tilt 16:0020:00 08:0020:00
Soiled cage08:00–20:00
Pair-housing20:00 08:00
Sucrose preference test10:00–12:00