Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Cold Allodynia in Rats

Figure 3

Effects of BVA in different doses of BV on oxaliplatin-induced cold allodynia. The behavioral tests for cold allodynia were performed before and after 2.5 mg/kg (a), 1.0 mg/kg (b), or 0.25 mg/kg (c) BVA treatment at GV3 acupoint (𝑛=4/group). In the control group (CON), only 0.05 cc of normal saline was injected (d). In BV1.0 and BV0.25 groups, the TWL after BVA significantly increased as compared with TWL before BVA. No significant difference between TWLs before and after injection was observed in BV2.5 and CON groups. Data are presented as mean ± SEM. ^∗𝑃<0.05, ^∗∗𝑃<0.01 by paired t-test.

(a)

(b)

(c)

(d)