Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway
Effects of PE on PCNA expression during DENA-initiated hepatocarcinogenesis in rats. (A) Representative immunohistochemical localization of PCNA (magnification: 100x). Arrows indicate immunohistochemical staining of PCNA. Several groups are (a) normal control; (b) DENA control; (c) PE 1 g/kg plus DENA; and (d) PE 10 g/kg plus DENA. (B) Quantification of PCNA-positive cells based on 1,000 hepatocytes per animal and 4 animals per group. Each bar represents the mean ± SEM (). as compared with normal group; as compared with DENA control.