Tropical Protozoan Diseases: Natural Product Drug Discovery and Development
Table 1
Protozoan infectious diseases.
Parasites
Disease
Occurrence
Mortality
DALYs
Plasmodium spp.
Malaria
219 million new cases*
660,000 deaths*
33,976,000
Leishmania spp.
Leishmaniasis
300,000 new cases of VL each year
Approx. 40,000 deaths due to VL
1,974,000**
1 million new cases of CL each year
Trypanosoma spp.
Human African trypanosomiasis
20,000 actual cases
1,673,000**
Chagas disease
Approx. 8 million cases***
12,000
430,000**
VL: visceral leishmaniasis, CL: cutaneous leishmaniasis, DALY’s: Disability Adjusted Life Years. In 2010, according to the World Malaria Report 2012. **The Global Burden of Disease Report, WHO, 2004. ***Second WHO Report on Neglected Tropical Diseases 2013.