Tropical Protozoan Diseases: Natural Product Drug Discovery and Development

Table 1

Protozoan infectious diseases.


Plasmodium spp.
Malaria219 million new cases*660,000 deaths*33,976,000
Leishmania spp.
Leishmaniasis300,000 new cases of VL each yearApprox. 40,000 deaths due to VL1,974,000**
1 million new cases of CL each year
Trypanosoma spp.Human African trypanosomiasis
20,000 actual cases1,673,000**
Chagas disease
Approx. 8 million cases***12,000 430,000**

VL: visceral leishmaniasis, CL: cutaneous leishmaniasis, DALY’s: Disability Adjusted Life Years.
In 2010, according to the World Malaria Report 2012. **The Global Burden of Disease Report, WHO, 2004. ***Second WHO Report on Neglected Tropical Diseases 2013.