Tropical Protozoan Diseases: Natural Product Drug Discovery and Development

Table 1

Protozoan infectious diseases.

Parasites	Disease	Occurrence	Mortality	DALYs
Plasmodium spp.	Malaria	219 million new cases*	660,000 deaths*	33,976,000
Leishmania spp.	Leishmaniasis	300,000 new cases of VL each year	Approx. 40,000 deaths due to VL	1,974,000**
		1 million new cases of CL each year
Trypanosoma spp.	Human African trypanosomiasis	20,000 actual cases		1,673,000**
	Chagas disease	Approx. 8 million cases***	12,000	430,000**

VL: visceral leishmaniasis, CL: cutaneous leishmaniasis, DALY’s: Disability Adjusted Life Years.
∗In 2010, according to the World Malaria Report 2012. **The Global Burden of Disease Report, WHO, 2004. ***Second WHO Report on Neglected Tropical Diseases 2013.