A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study

Figure 3

Bone mineral density (BMD) in vertebra and femur of sham-operated mice (SHAM), ovariectomized mice administered with vehicle (OVX), different dosages (50, 75, and 100 mg/kg) of VtR (OVX-VtR-50, -VtR-75, and -VtR-100), or 17β-estradiol (OVX-E) for 8 weeks. Values are mean (𝑛=10) with their standard error of mean (S.E.M.) represented by vertical bars. ^#𝑃<0.01, significantly different from the SHAM group; *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001, significantly different from the OVX group.

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