Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 409421, 14 pages
http://dx.doi.org/10.1155/2013/409421
Research Article

A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study

1National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nong Street, Beitou District, Taipei 11221, Taiwan
2Department of Cosmetic Science, Chang Gung University of Science and Technology, No. 261, Wen-hwa 1st road, Kwei-shan, Taoyuan 333, Taiwan
3Department of Biotechnology, Hungkuang University, No. 1018, Section 6, Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan

Received 24 January 2013; Accepted 13 March 2013

Academic Editor: Jae Youl Cho

Copyright © 2013 Yu-Ling Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Klibanski, L. Adams-Campbell, T. Bassford et al., “Osteoporosis prevention, diagnosis, and therapy,” Journal of the American Medical Association, vol. 285, no. 6, pp. 785–795, 2001. View at Google Scholar
  2. G. A. Rodan and T. J. Martin, “Therapeutic approaches to bone diseases,” Science, vol. 289, no. 5484, pp. 1508–1514, 2000. View at Google Scholar
  3. N. Y. Chiu and K. H. Chang, The Illustrated Medicinal Plants of Taiwan, SMC Publishing, Taipei, Taiwan, 4th edition, 1995.
  4. Y. S. Lin, Y. L. Lu, G. J. Wang, L. G. Chen, C. L. Wen, and W. C. Hou, “Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities,” Journal of Agricultural and Food Chemistry, vol. 60, no. 30, pp. 7435–7441, 2012. View at Google Scholar
  5. S. W. Kang, M. S. Kim, H. S. Kim, Y. J. Lee, and Y. H. Kang, “Anti-atherogenic activity of wild grape (Vitis thunbergii) extract antagonizing smooth muscle cell proliferation and migration promoted by neighboring macrophages,” International Journal of Molecular Medicine, vol. 29, no. 6, pp. 1137–1145, 2012. View at Google Scholar
  6. J. S. Deng, Y. C. Chang, C. L. Wen et al., “Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities,” Journal of Ethnopharmacology, vol. 142, no. 3, pp. 795–803, 2012. View at Google Scholar
  7. K. T. Wang, L. G. Chen, S. H. Tseng, J. S. Huang, M. S. Hsieh, and C. C. Wang, “Anti-inflammatory effects of resveratrol and oligostilbenes from Vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis,” Journal of Agricultural and Food Chemistry, vol. 59, no. 8, pp. 3649–3656, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. L. Huang, W. J. Tsai, C. C. Shen, and C. C. Chen, “Resveratrol derivatives from the roots of Vitis thunbergii,” Journal of Natural Products, vol. 68, no. 2, pp. 217–220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. W. F. Chiou, C. C. Shen, C. C. Chen, C. H. Lin, and Y. L. Huang, “Oligostilbenes from the roots of Vitis thunbergii,” Planta Medica, vol. 75, no. 8, pp. 856–859, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Y. Peng, L. Y. Horng, H. C. Sung, H. C. Huang, and R. T. Wu, “Antiosteoporotic activity of Dioscorea alata L. cv. Phyto through driving mesenchymal stem cells differentiation for bone formation,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 712892, 12 pages, 2011. View at Publisher · View at Google Scholar
  11. Q. C. Liao, Z. S. Xiao, Y. F. Qin, and H. H. Zhou, “Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture,” Acta Pharmacologica Sinica, vol. 28, no. 10, pp. 1597–1602, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. W. F. Chiou, J. F. Liao, C. Y. Huang, and C. C. Chen, “2-Methoxystypandrone represses RANKL-mediated osteoclastogenesis by down-regulating formation of TRAF6-TAK1 signalling complexes,” British Journal of Pharmacology, vol. 161, no. 2, pp. 321–335, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. C. H. Lee, Y. L. Huang, J. F. Liao, and W. F. Chiou, “Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway,” European Journal of Pharmacology, vol. 676, no. 1–3, pp. 26–33, 2012. View at Google Scholar
  14. C. H. Lee, Y. L. Huang, J. F. Liao, and W. F. Chiou, “Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix,” European Journal of Pharmacology, vol. 668, no. 3, pp. 383–389, 2011. View at Google Scholar
  15. A. I. Idris, I. R. Greig, E. Bassonga-Landao, S. H. Ralston, and R. J. Van't Hof, “Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation,” Endocrinology, vol. 150, no. 1, pp. 5–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. D. N. Kalu, “The ovariectomized rat model of postmenopausal bone loss,” Bone and Mineral, vol. 15, no. 3, pp. 175–191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Szulc and P. D. Delmas, “Biochemical markers of bone turnover in men,” Calcified Tissue International, vol. 69, no. 4, pp. 229–234, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Hertrampf, B. Schleipen, M. Velders, U. Laudenbach, K. H. Fritzemeier, and P. Diel, “Estrogen receptor subtype-specific effects on markers of bone homeostasis,” Molecular and Cellular Endocrinology, vol. 291, no. 1-2, pp. 104–108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. U. H. Lerner, “Bone remodeling in post-menopausal osteoporosis,” Journal of Dental Research, vol. 85, no. 7, pp. 584–595, 2006. View at Google Scholar · View at Scopus
  20. T. J. Wronski, P. L. Lowry, C. C. Walsh, and L. A. Ignaszewski, “Skeletal alterations in ovariectomized rats,” Calcified Tissue International, vol. 37, no. 3, pp. 324–328, 1985. View at Google Scholar · View at Scopus
  21. D. Wagner and A. Fahrleitner-Pammer, “Levels of osteoprotegerin (OPG) and receptor activator for nuclear factor kappa B ligand (RANKL) in serum: are they of any help?” Wiener Medizinische Wochenschrift, vol. 160, no. 17-18, pp. 452–457, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. N. G. Angelopoulos, A. Goula, E. Katounda et al., “Circulating osteoprotegerin and receptor activator of NF-κB ligand system in patients with β-thalassemia major,” Journal of Bone and Mineral Metabolism, vol. 25, no. 1, pp. 60–67, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. E. Nadia, A. S. Nazrun, M. Norazlina, N. M. Isa, M. Norliza, and S. Ima Nirwana, “The anti-inflammatory, phytoestrogenic, and antioxidative role of Labisia pumila in prevention of postmenopausal osteoporosis,” Advances in Pharmacological Sciences, vol. 2012, Article ID 706905, 2012. View at Publisher · View at Google Scholar
  24. M. Notoya, R. Arai, T. Katafuchi, N. Minamino, and H. Hagiwara, “A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts,” European Journal of Pharmacology, vol. 560, no. 2-3, pp. 234–239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Xing, S. Oparil, H. Yu et al., “Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β,” PLoS ONE, vol. 7, no. 6, Article ID e36890, 2012. View at Google Scholar
  26. H. Hotokezaka, E. Sakai, N. Ohara et al., “Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-α, lipopolysaccharide, or peptidoglycan,” Journal of Cellular Biochemistry, vol. 101, no. 1, pp. 122–134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Hikiji, T. Takato, T. Shimizu, and S. Ishii, “The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease,” Progress in Lipid Research, vol. 47, no. 2, pp. 107–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. K. T. Ku, Y. L. Huang, Y. J. Huang, and W. F. Chiou, “Miyabenol A inhibits LPS-induced NO production via IKK/IκB inactivation in RAW 264.7 macrophages: possible involvement of the p38 and PI3K pathways,” Journal of Agricultural and Food Chemistry, vol. 56, no. 19, pp. 8911–8918, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Sakurai, K. Kitadate, H. Nishioka et al., “Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages,” Journal of Nutritional Biochemistry, vol. 21, no. 1, pp. 47–54, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. F. P. Ross, “Interleukin 7 and estrogen-induced bone loss,” Trends in Endocrinology and Metabolism, vol. 14, no. 4, pp. 147–149, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. M. N. Weitzmann, S. Cenci, L. Rifas, C. Brown, and R. Pacifici, “Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines,” Blood, vol. 96, no. 5, pp. 1873–1878, 2000. View at Google Scholar · View at Scopus
  32. C. Miyaura, Y. Onoe, M. Inada et al., “Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 17, pp. 9360–9365, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Toraldo, C. Roggia, W. P. Qian, R. Pacific, and M. N. Weitzmann, “IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 1, pp. 125–130, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Sato, K. Watanabe, M. Masuhara, N. Hada, and Y. Hakeda, “Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro,” Journal of Bone and Mineral Metabolism, vol. 25, no. 1, pp. 19–27, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. M. N. Weitzmann, C. Roggia, G. Toraldo, L. Weitzmann, and R. Pacifici, “Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency,” Journal of Clinical Investigation, vol. 110, no. 11, pp. 1643–1650, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. M. N. Weitzmann and R. Pacifici, “Estrogen regulation of immune cell bone interactions,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 256–274, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Owen and A. J. Friedenstein, “Stromal stem cells: marrow-derived osteogenic precursors,” Ciba Foundation Symposium, vol. 136, pp. 42–60, 1988. View at Google Scholar · View at Scopus
  38. N. Udagawa, N. Takahashi, T. Akatsu et al., “Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 18, pp. 7260–7264, 1990. View at Google Scholar · View at Scopus
  39. M. Asagiri and H. Takayanagi, “The molecular understanding of osteoclast differentiation,” Bone, vol. 40, no. 2, pp. 251–264, 2007. View at Publisher · View at Google Scholar · View at Scopus