A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study

Table 1

Effects of VtR on the serum levels of biochemical markers in OVX mice.

Groups	Osteocalcin (ng/mL)	CTx; (ng/mL)	RANKL/OPG; (ratio)	IL-7; (pg/mL)
SHAM	17.1 ± 1.5	16.4 ± 0.4	0.31 ± 0.02	0.32 ± 0.05
OVX	23.7 ± 1.4^#	19.8 ± 0.5^##	0.83 ± 0.04^##	1.67 ± 0.13^##
OVX-VtR-50	22.5 ± 2.2	18.6 ± 0.6	0.88 ± 0.08	1.53 ± 0.28
OVX-VtR-75	27.6 ± 1.7*	16.9 ± 0.7*	0.72 ± 0.03*	0.52 ± 0.19**
OVX-VtR-100	29.3 ± 2.0**	16.3 ± 0.9**	0.42 ± 0.06**	0.39 ± 0.12***
OVX-E	19.4 ± 2.6*	16.4 ± 0.5	0.38 ± 0.07**	0.27 ± 0.08***

Serum levels of biochemical markers in sham-operated mice (SHAM), ovariectomized mice administrated with vehicle (OVX), different dosages (50, 75, and 100 mg/kg) of VtR (OVX-VtR-50, -VtR-75, and -VtR-100), or 17β-estradiol (OVX-E) for 8 weeks. The values represent the means ± S.E.M. ^#P < 0.05 and ^##P < 0.01, versus sham control; *P < 0.05, **P < 0.01, and ***P < 0.001, versus OVX. 𝑛 = 8–10 samples per group.