Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 1 / Review Article
Phytochemical and Pharmacological Review of Da Chuanxiong Formula: A Famous Herb Pair Composed of Chuanxiong Rhizoma and Gastrodiae Rhizoma for Headache Table 1 Main chemical constituents and relative detection methods of CR.
Compound type Compound name Extract Detection method References Phthalide compounds (Figure 1 ) Z-6,8′,7,3′-Diligustilide Ethanol
1 H-NMR/13 C-NMR[16 ] Diethyl ether
13 C-NMR[17 ] Ethanol
1 H-NMR/13 C-NMR[16 ] 60% ethanol LC-ESI-MS [18 ] 95% ethanol TOF-MS/NMR [19 ] Diethyl ether
13 C-NMR[17 ] Z′′-3,8-Dihydro-6,6′,7,3′α -diligustilide Diethyl ether
13 C-NMR[17 ] 4-Hydroxy-3-butylphthalide 80% methano HPLC [20 ] Acetic ether MS [21 ] 95% ethanol TOF-MS/NMR [19 ] Ligustilide Acetic ether GC-MS [22 ] 80% methanol HPLC [20 ] 60% ethanol LC-ESI-MS [18 ] Ethanol
1 H-NMR/13 C-NMR[16 ] Senkyunolide F Acetic ether MS [21 ] Senkyunolide I 95% ethanol TOF-MS/NMR [19 ] Acetic ether MS [21 ] Senkyunolide P 60% ethanol LC-ESI-MS [18 ] 4,5-Dihydro-3-butylphthalide Diethyl ether
13 C-NMR[17 ] Chuanxiongol 80% methanol HPLC [20 ] 6,7-di-Hydroxyligustilide 80% methanol HPLC [20 ] 3-n-Butylphthalide 60% ethanol LC-ESI-MS [18 ] Acetic ether GC-MS [22 ] Organic acids (Figure 2 )
Feulic acid Ethanol
1 H-NMR[23 ] 95% ethanol NMR [19 ] Ethanol IR/1 H-NMR [24 ] 80% methanol HPLC [20 ] 60% ethanol LC-ESI-MS [18 ] Caffeic acid 95% ethanol NMR [19 ] Ethanol IR/1 H-NMR [24 ] 80% methanol HPLC [20 ] Succinic acid 95% ethanol NMR [19 ] Sadanic acid Ethanol IR/1 H-NMR [24 ] Sinapic acid Ethanol
1 H-NMR[23 ] Protocatechuic acid 80% methanol HPLC [20 ] Augustic acid Acetic ether MS [21 ] Phenols (Figure 3 ) Chrysophanol Ethanol IR/1 H-NMR [24 ] Pregnenlone Ethanol
1 H-NMR[23 ] 95% ethanol NMR [19 ] Acetic ether MS [21 ] 95% ethanol NMR [19 ] Water EI-MS/FAB-MS [21 ] Essential oil (Figure 4 ) Xiongterpene Acetic ether MS [21 ] 95% ethanol NMR [19 ] (4S)-p-menth-1-ene-4,7-diol Acetic ether MS [21 ] Water EI-MS/FAB-MS [21 ] 3(R), 8(S), 9(Z)-Falcarindiol Acetic ether MS [21 ] Water EI-MS/FAB-MS [21 ] 1,7,7-Trimethyl-bicyclo[2.2.1]hept-2-yl Acetic ether GC-MS [22 ] b-Phellandrene Acetic ether GC-MS [22 ] γ -TerpineneAcetic ether GC-MS [22 ] (R)-(−)-p-menth-1-en-4-ol Acetic ether GC-MS [22 ] p-Mentha-1,4(8)-diene Acetic ether GC-MS [22 ] Monopalmitin 95% ethanol NMR [19 ] (−)-Spathulenol Acetic ether GC-MS [22 ] 2-Chloro-1-(2,4-dimethylphenyl)-2-methyl-1-propanone Acetic ether GC-MS [22 ] Alkaloid (Figure 5 ) Tetramethylpyrazine 80% methanol HPLC [20 ] Choline 80% methanol HPLC [20 ]