5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing  Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins

<table>Influence of 5,7-dihydroxyflavone on the expression of c-IAP1, c-IAP2, XIAP, and Survivin. (a) HepG2 cells were treated with the indicated concentrations of 5,7-dihydroxyflavone for 24 h. Western blotting was performed to determine the protein levels of c-IAP1, c-IAP2, XIAP, and Survivin. GADPH was used as loading control. (b)–(e) the relative densities of these proteins were determined following densitometric measurements of the specific protein bands and normalization against the value of GAPDH. The asterisk indicates a significant difference (<svg height="13.95" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 73.300003 13.95" width="73.300003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) compared with control. Data are mean ± SD.</table>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing  Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins 