5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing  Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins

<table>Influence of 5,7-dihydroxyflavone on the activation of Akt, STAT3, and MAPK. (a) HepG2 cells were treated with the indicated concentrations of 5,7-dihydroxyflavone for 24 h. Western blotting was performed to determine the phosphorylation levels of Akt, STAT3, and mitogen-activated protein kinase (MAPK). GADPH was used as loading control. (b, c), the relative densities of phospho-Akt and phosphor-STAT3 were determined following densitometric measurements of the specific protein bands and normalization against the value of total Akt and STAT3, respectively. The asterisk indicates a significant difference (<svg height="13.95" id="M20" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 73.300003 13.95" width="73.300003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) compared with control. Data are mean ± SD.</table>

Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing  Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins 