Research Article
Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi
Table 1
In vitro trypanocidal activity (IC
50 values in
g/mL) of mixtures of lupenone and caryophyllene oxide.
| | Sample | Trypanosoma cruzi
Tulahuen strain | FIC |
| | SYH | 74.5 g/mL | — | | FHex | 61.5 g/mL | — | Lupenone + caryophyllene oxide
1 : 0 | 85.0 g/mL | — | Lupenone + caryophyllene oxide
4 : 1 | >100 g/mL | 5.62 | Lupenone + caryophyllene oxide
3 : 2 | 80.0 g/mL | 3.59 | Lupenone + caryophyllene oxide
1 : 1 | 86.5 g/mL | 3.88 |
Lupenone + caryophyllene oxide
1 : 4 | 10.4 g/mL
| 0.46 | Lupenone + caryophyllene oxide
2 : 3 | 39.8 g/mL | 1.79 | Lupenone + caryophyllene oxide
0 : 1 | 30.1 g/mL | — | | Anfotericina B | 0.7 g/mL | — |
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FIC: fractional inhibitory concentrations; SYH: leaf extract of Serjania yucatanensis; FHex: hexane fraction.
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