Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 437948, 17 pages
http://dx.doi.org/10.1155/2013/437948
Review Article

Herbal Medicine and Acupuncture for Breast Cancer Palliative Care and Adjuvant Therapy

1Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
2Agricultural Biotechnology Research Center, Academia Sinica, No. 128, Section 2, Academia Road, Nankang, Taipei 115, Taiwan
3Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan

Received 21 March 2013; Revised 14 May 2013; Accepted 21 May 2013

Academic Editor: Yoshiharu Motoo

Copyright © 2013 Guo-Shiou Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Cancer Society, Global Cancer Facts & Figures, American Cancer Society, Atlanta, Ga, USA, 2nd edition, 2011.
  2. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. S. Araújo, I. L. Farias, J. Gutierres et al., “Uncaria tomentosa—adjuvant treatment for Breast Cancer: clinical trial,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 676984, 8 pages, 2012. View at Publisher · View at Google Scholar
  4. US Preventive Services Task Force, “Screening for Breast Cancer,” http://www.uspreventiveservicestaskforce.org/uspstf/uspsbrca.htm, 2009.
  5. Canadian Task Force on Preventive Health Care, “Screening for breast cancer,” www.canadiantaskforce.ca/guidelines/2011-breast-cancer/, 2011.
  6. J. T. Anim, B. John, S. A. AbdulSathar S et al., “Relationship between the expression of various markers and prognostic factors in breast cancer,” Acta Histochemica, vol. 107, no. 2, pp. 87–93, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Kado, A. Forsyth, P. Patel, and J. Schwartz, “Dietary supplements and natural products in Breast Cancer trials,” Frontiers in Bioscience, vol. 4, pp. 546–567, 2012. View at Google Scholar
  8. H. Ozer, J. O. Armitage, C. L. Bennett et al., “Update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines,” Journal of Clinical Oncology, vol. 18, no. 20, pp. 3558–3585, 2000. View at Google Scholar · View at Scopus
  9. C. F. Higgins, “Multiple molecular mechanisms for multidrug resistance transporters,” Nature, vol. 446, no. 7137, pp. 749–757, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Z. Wang, T. Calway, and C. S. Yuan, “Herbal medicines as adjuvants for Cancer therapeutics,” The American Journal of Chinese Medicine, vol. 40, no. 4, pp. 657–669, 2012. View at Google Scholar
  11. World Health Organization, Guidelines on Safety Monitoring of Herbal Medicines in Pharmacovigilance Systems, World Health Organization, Geneva, Switzerland, 2004.
  12. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), “Effects of chemo-therapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials,” The Lancet, vol. 365, no. 9472, pp. 1687–1717, 2005. View at Google Scholar
  13. A. H. Partridge, H. J. Burstein, and E. P. Winer, “Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer,” Journal of the National Cancer Institute. Monographs, no. 30, pp. 135–142, 2001. View at Google Scholar · View at Scopus
  14. M. N. Fornier, “Approved agents for metastatic breast cancer,” Seminars in Oncology, vol. 38, supplement 2, pp. S3–S10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Tagliaferri, I. Cohen, and D. Tripathy, “Complementary and alternative medicine in early-stage breast cancer,” Seminars in Oncology, vol. 28, no. 1, pp. 121–134, 2001. View at Google Scholar · View at Scopus
  16. C. Yang, L. Y. Chien, and C. J. Tai, “Use of complementary and alternative medicine among patients with cancer receiving outpatient chemotherapy in Taiwan,” Journal of Alternative and Complementary Medicine, vol. 14, no. 4, pp. 413–416, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. R. E. Patterson, M. L. Neuhouser, M. M. Hedderson et al., “Types of alternative medicine used by patients with breast, colon, or prostate cancer: predictors, motives, and costs,” Journal of Alternative and Complementary Medicine, vol. 8, no. 4, pp. 477–485, 2002. View at Google Scholar · View at Scopus
  18. L. K. Helyer, S. Chin, B. K. Chui et al., “The use of complementary and alternative medicines among patients with locally advanced breast cancer—a descriptive study,” BMC Cancer, vol. 6, article 39, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Shen, R. Andersen, P. S. Albert et al., “Use of complementary/alternative therapies by women with advanced-stage breast cancer,” BMC Complementary and Alternative Medicine, vol. 2, no. 8, 2002. View at Google Scholar
  20. M. A. Navo, J. Phan, C. Vaughan et al., “An assessment of the utilization of complementary and alternative medication in women with gynecologic or breast malignancies,” Journal of Clinical Oncology, vol. 22, no. 4, pp. 671–677, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Risberg, A. Kolstad, Y. Bremnes et al., “Knowledge of and attitudes toward complementary and alternative therapies: a national multicentre study of oncology professionals in Norway,” European Journal of Cancer, vol. 40, no. 4, pp. 529–535, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Münstedt, A. Entezami, A. Wartenberg, and U. Kullmer, “The attitudes of physicians and oncologists towards unconventional cancer therapies (UCT),” European Journal of Cancer, vol. 36, no. 16, pp. 2090–2095, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Harris and R. Rees, “The prevalence of complementary and alternative medicine use among the general population: a systematic review of the literature,” Complementary Therapies in Medicine, vol. 8, no. 2, pp. 88–96, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Nishimura, G. A. Plotnikoff, and K. Watanabe, “Kampo medicine as an integrative medicine in Japan,” Japan Medical Association Journal, vol. 52, no. 3, pp. 147–149, 2009. View at Google Scholar · View at Scopus
  25. H. L. Park, H. S. Lee, B. C. Shin et al., “Traditional medicine in China, Korea, and Japan: a brief introduction and comparison,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 429103, 9 pages, 2012. View at Publisher · View at Google Scholar
  26. A. Sparreboom, M. C. Cox, M. R. Acharya, and W. D. Figg, “Herbal remedies in the United States: potential adverse interactions with anticancer agents,” Journal of Clinical Oncology, vol. 22, no. 12, pp. 2489–2503, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. D. M. Eisenberg, R. C. Kessler, M. I. Van Rompay et al., “Perceptions about complementary therapies relative to conventional therapies among adults who use both: results from a national survey,” Annals of Internal Medicine, vol. 135, no. 5, pp. 344–351, 2001. View at Google Scholar · View at Scopus
  28. Z. Hu, X. Yang, P. C. L. Ho et al., “Herb-drug interactions: a literature review,” Drugs, vol. 65, no. 9, pp. 1239–1282, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. M. B. Cleary-Guida, H. A. Okvat, M. C. Oz, and W. Ting, “A regional survey of health insurance coverage for complementary and alternative medicine: current status and future ramifications,” Journal of Alternative and Complementary Medicine, vol. 7, no. 3, pp. 269–273, 2001. View at Google Scholar · View at Scopus
  30. A. K. Garg, T. A. Buchholz, and B. B. Aggarwal, “Chemosensitization and radiosensitization of tumors by plant polyphenols,” Antioxidants and Redox Signaling, vol. 7, no. 11-12, pp. 1630–1647, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. V. B. Konkimalla and T. Efferth, “Evidence-based Chinese medicine for cancer therapy,” Journal of Ethnopharmacology, vol. 116, no. 2, pp. 207–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Hann, F. Baker, M. Denniston, and N. Entrekin, “Long-term breast cancer survivors' use of complementary therapies: perceived impact on recovery and prevention of recurrence,” Integrative Cancer Therapies, vol. 4, no. 1, pp. 14–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Efferth, P. C. H. Li, V. S. B. Konkimalla, and B. Kaina, “From traditional Chinese medicine to rational cancer therapy,” Trends in Molecular Medicine, vol. 13, no. 8, pp. 353–361, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Yang, L. Chien, and C. Tai, “Use of complementary and alternative medicine among patients with cancer receiving outpatient chemotherapy in Taiwan,” Journal of Alternative and Complementary Medicine, vol. 14, no. 4, pp. 413–416, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. A. M. Gross, Q. Liu, and S. Bauer-Wu, “Prevalence and predictors of complementary therapy use in advanced-stage breast cancer patients,” Journal of Oncology Practice, vol. 3, no. 6, pp. 292–295, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. J. L. McQuade, Z. Meng, Z. Chen et al., “Utilization of and attitudes towards traditional Chinese medicine therapies in a Chinese Cancer hospital: a survey of patients and physicians,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 504507, 11 pages, 2012. View at Publisher · View at Google Scholar
  37. G. E. Deng, M. Frenkel, L. Cohen et al., “Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals,” Journal of the Society for Integrative Oncology, vol. 7, no. 3, pp. 85–120, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Deng and B. R. Cassileth, “Integrative oncology: complementary therapies for pain, anxiety, and mood disturbance,” CA: A Cancer Journal for Clinicians, vol. 55, no. 2, pp. 109–116, 2005. View at Google Scholar · View at Scopus
  39. E. C. Devine and S. K. Westlake, “The effects of psychoeducational care provided to adults with cancer: meta-analysis of 116 studies,” Oncology Nursing Forum, vol. 22, no. 9, pp. 1369–1381, 1995. View at Google Scholar · View at Scopus
  40. D. Seely and D. Oneschuk, “Interactions of natural health products with biomedical cancer treatments,” Current Oncology, vol. 15, supplement 2, pp. 81–86, 2008. View at Google Scholar
  41. D. O'Regan and J. Filshie, “Acupuncture and cancer,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 96–100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Saquib, L. Madlensky, S. Kealey et al., “Classification of CAM use and its correlates in patients with early-stage breast cancer,” Integrative Cancer Therapies, vol. 10, no. 2, pp. 138–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Gerber, C. Scholz, T. Reimer, V. Briese, and W. Janni, “Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review,” Breast Cancer Research and Treatment, vol. 95, no. 3, pp. 199–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. Z. Nahleh and I. A. Tabbara, “Complementary and alternative medicine in breast cancer patients,” Palliative & Supportive Care, vol. 1, no. 3, pp. 267–273, 2003. View at Google Scholar · View at Scopus
  45. E. A. Lammerink, G. H. de Bock, C. P. Schröder, and M. J. Mourits, “The management of menopausal symptoms in breast cancer survivors: case-based approach,” Maturitas, vol. 73, no. 3, pp. 265–268, 2012. View at Google Scholar
  46. H. Kang, D. Jeong, D. Kim, and M. S. Lee, “The use of acupuncture for managing gynaecologic conditions: an overview of systematic reviews,” Maturitas, vol. 68, no. 4, pp. 346–354, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Loibl, A. Lintermans, A. S. Dieudonné, and P. Neven, “Management of menopausal symptoms in breast cancer patients,” Maturitas, vol. 68, no. 2, pp. 148–154, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. “Practicing Chiropractors' Committee on Radiology Protocols,” http://www.pccrp.org/docs/PCCRP%20Section%20I.pdf, 2013.
  49. US Department of Heath and Human Services and Agency for Healthcare Research and Quality, http://www.ahrq.gov, 2013.
  50. G. Del Rio, S. Zironi, L. Valeriani et al., “Weight gain in women with breast cancer treated with adjuvant cyclophosphomide, methotrexate and 5-fluorouracil. Analysis of resting energy expenditure and body composition,” Breast Cancer Research and Treatment, vol. 73, no. 3, pp. 267–273, 2002. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Weis, “Cancer-related fatigue: prevalence, assessment and treatment strategies,” Expert Review of Pharmacoeconomics and Outcomes Research, vol. 11, no. 4, pp. 441–446, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. R. Stasi, L. Abriani, P. Beccaglia, E. Terzoli, and S. Amadori, “Cancer-related fatigue: evolving concepts in evaluation and treatment,” Cancer, vol. 98, no. 9, pp. 1786–1801, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. G. F. V. Ismael, D. D. Rosa, M. S. Mano, and A. Awada, “Novel cytotoxic drugs: old challenges, new solutions,” Cancer Treatment Reviews, vol. 34, no. 1, pp. 81–91, 2008. View at Publisher · View at Google Scholar · View at Scopus
  54. X. Yao, K. Panichpisal, N. Kurtzman, and K. Nugent, “Cisplatin nephrotoxicity: a review,” American Journal of the Medical Sciences, vol. 334, no. 2, pp. 115–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Christie, M. M. Acharya, V. K. Parihar, A. Nguyen, V. Martirosian, and C. L. Limoli, “Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy,” Clinical Cancer Research, vol. 18, no. 7, pp. 1954–1965, 2012. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Gianni, B. F. Cole, I. Panzini et al., “Anemia during adjuvant non-taxane chemotherapy for early breast cancer: incidence and risk factors from two trials of the International Breast Cancer Study Group,” Supportive Care in Cancer, vol. 16, no. 1, pp. 67–74, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. R. Ochoa, P. A. Bejarano, S. Glück, and A. J. Montero, “Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review,” Journal of Medical Case Reports, vol. 6, article 413, 2012. View at Google Scholar
  58. A. F. Carrion, P. J. Hosein, E. M. Cooper, G. Lopes, L. Pelaez, and C. M. Rocha-Lima, “Severe colitis associated with docetaxel use: a report of four cases,” World Journal of Gastrointestinal Oncology, vol. 2, no. 10, pp. 390–394, 2010. View at Google Scholar
  59. M. Crump, D. Tu, L. Shepherd, M. Levine, V. Bramwell, and K. Pritchard, “Risk of acute leukemia following epirubicin-based adjuvant chemotherapy: a report from the National Cancer Institute of Canada Clinical Trials Group,” Journal of Clinical Oncology, vol. 21, no. 16, pp. 3066–3071, 2003. View at Publisher · View at Google Scholar · View at Scopus
  60. C. J. Poole, H. M. Earl, L. Hiller et al., “Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer,” The New England Journal of Medicine, vol. 355, no. 18, pp. 1851–1862, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. K. A. Amin, B. M. Mohamed, M. A. El-Wakil, and S. O. Ibrahem, “Impact of breast cancer and combination chemotherapy on oxidative stress, hepatic and cardiac markers,” Journal of Breast Cancer, vol. 15, no. 3, pp. 306–312, 2012. View at Google Scholar
  62. G. P. Stathopoulos, J. Koutantos, H. Lazaki, S. K. Rigatos, J. Stathopoulos, and G. Deliconstantinos, “Capecitabine (Xeloda) as monotherapy in advanced breast and colorectal cancer: effectiveness and side-effects,” Anticancer Research, vol. 27, no. 3B, pp. 1653–1656, 2007. View at Google Scholar · View at Scopus
  63. K. D. Chandwani, J. L. Ryan, L. J. Peppone et al., “Cancer-related stress and complementary and alternative medicine: a review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 979213, 15 pages, 2012. View at Google Scholar
  64. T. J. Powles, A. L. Jones, I. R. Judson, J. R. Hardy, and S. E. Ashley, “A randomised trial comparing combination chemotherapy using mitomycin C, mitozantrone and methotrexate (3M) with vincristine, anthracycline and cyclophosphamide (VAC) in advanced breast cancer,” British Journal of Cancer, vol. 64, no. 2, pp. 406–410, 1991. View at Google Scholar · View at Scopus
  65. U. S. National Cancer Institute, www.cancer.gov/cancertopics/druginfo/breastcancer, 2012.
  66. Z. Ghoreishi, A. Esfahani, A. Djazayeri et al., “Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial,” BMC Cancer, vol. 12, pp. 355–363, 2012. View at Google Scholar
  67. S. Saibil, B. Fitzgerald, O. C. Freedman et al., “Incidence of taxane-induced pain and distress in patients receiving chemotherapy for early-stage breast cancer: a retrospective, outcomes-based survey,” Current Oncology, vol. 17, no. 4, pp. 42–47, 2010. View at Google Scholar · View at Scopus
  68. B. Fisher, J. P. Costantino, D. L. Wickerham et al., “Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study,” Journal of the National Cancer Institute, vol. 97, no. 22, pp. 1652–1662, 2005. View at Publisher · View at Google Scholar · View at Scopus
  69. A. Sparber, L. Bauer, G. Curt et al., “Use of complementary medicine by adult patients participating in cancer clinical trials,” Oncology Nursing Forum, vol. 27, no. 4, pp. 623–630, 2000. View at Google Scholar · View at Scopus
  70. J. Lu, J. Bao, X. Chen, M. Huang, and Y. Wang, “Alkaloids isolated from natural herbs as the anticancer agents,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 485042, 12 pages, 2012. View at Publisher · View at Google Scholar
  71. Z. Xu, X. Chen, Z. Zhong, L. Chen, and Y. Wang, “Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities,” American Journal of Chinese Medicine, vol. 39, no. 1, pp. 15–27, 2011. View at Publisher · View at Google Scholar · View at Scopus
  72. H. Liao, M. Lu, H. Chang et al., “Effects of herbal medicinal formulas on suppressing viral replication and modulating immune responses,” American Journal of Chinese Medicine, vol. 38, no. 1, pp. 173–190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  73. J. N. Lai, C. T. Wu, and J. D. Wang, “Prescription pattern of Chinese herbal products for Breast Cancer in Taiwan: a population-based study,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 891893, 7 pages, 2012. View at Publisher · View at Google Scholar
  74. T. Yasui, S. Matsui, S. Yamamoto et al., “Effects of Japanese traditional medicines on circulating cytokine levels in women with hot flashes,” Menopause, vol. 18, no. 1, pp. 85–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. B. Yang, H. Li, Y. Qi, and M. Lu, “Clinical study on treatment of mammary cancer by Shenqi Fuzheng Injection in cooperation with chemotherapy,” Chinese Journal of Integrative Medicine, vol. 13, no. 1, pp. 37–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. N. Yaal-Hahoshen, Y. Maimon, N. Siegelmann-Danieli et al., “A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer,” Oncologist, vol. 16, no. 9, pp. 1197–1202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  77. L. P. Liu, J. F. Liu, and Y. Q. Lu, “Effects of Sheng-Mai injection on the PRPP synthetase activity in BFU-es and CFU-es from bone marrows of mice with benzene-induced aplastic anemia,” Life Sciences, no. 69, pp. 1373–1379, 2001. View at Google Scholar
  78. M. Wang, J. Li, H. Di et al., “Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia,” Chinese Journal of Integrative Medicine, vol. 13, no. 2, pp. 98–102, 2007. View at Publisher · View at Google Scholar · View at Scopus
  79. H. Que, H. Chen, S. Gao et al., “Effect of Runing II on the growth and metastasis of transplanted tumor in mammary cancer-bearing mice and its mechanism,” Journal of Traditional Chinese Medicine, vol. 28, no. 4, pp. 293–298, 2008. View at Google Scholar · View at Scopus
  80. S. Liu, Y. Hua, Z. Sun, S. Tan, and D. Lu, “Clinical observation of Ruyiping in preventing recidivation and metastasis of breast cancer,” Journal of Chinese Integrative Medicine, vol. 5, no. 2, pp. 147–149, 2007. View at Google Scholar · View at Scopus
  81. Z. Dai, X. Wang, H. Kang et al., “Clinical effects of Shenqi Fuzheng Injection in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets,” Journal of Traditional Chinese Medicine, vol. 28, no. 1, pp. 34–38, 2008. View at Google Scholar · View at Scopus
  82. M. F. Miller, K. M. Bellizzi, M. Sufian, A. H. Ambs, M. S. Goldstein, and R. Ballard-Barbash, “Dietary supplement use in individuals living with Cancer and other chronic conditions: a population-based study,” Journal of the American Dietetic Association, vol. 108, no. 3, pp. 483–494, 2008. View at Publisher · View at Google Scholar · View at Scopus
  83. J. Jiang, A. Thyagarajan-Sahu, J. Loganathan et al., “BreastDefend prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer,” Oncology Reports, vol. 28, no. 4, pp. 1139–1145, 2012. View at Google Scholar
  84. J. Jiang, R. Wojnowski, A. Jedinak, and D. Sliva, “Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend,” Integrative Cancer Therapies, vol. 10, no. 2, pp. 192–200, 2011. View at Publisher · View at Google Scholar · View at Scopus
  85. S. R. Zhuang, H. F. Chiu, S. L. Chen et al., “Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients,” British Journal of Nutrition, vol. 107, no. 5, pp. 712–718, 2012. View at Publisher · View at Google Scholar · View at Scopus
  86. S. Zhuang, S. Chen, J. Tsai et al., “Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy,” Phytotherapy Research, vol. 23, no. 6, pp. 785–790, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. H. S. Li, B. Yang, and X. C. Su, “Effect of shenqi fuzheng injection on repairing the immune function in patients with breast cancer,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 29, no. 6, pp. 537–539, 2009. View at Google Scholar · View at Scopus
  88. T. Mellios, H. L. Ko, and J. Beuth, “Impact of adjuvant chemo- and radiotherapy on the cellular immune system of breast cancer patients,” In Vivo, vol. 24, no. 2, pp. 227–230, 2010. View at Google Scholar · View at Scopus
  89. C. Wong, Y. Bao, E. L. Wong, P. Leung, K. P. Fung, and C. W. K. Lam, “Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients,” American Journal of Chinese Medicine, vol. 33, no. 3, pp. 381–395, 2005. View at Publisher · View at Google Scholar · View at Scopus
  90. W. Yang, J. Ju, M. J. Jeon, X. Han, and I. Shin, “Danshen (Salvia miltiorrhiza) extract inhibits proliferation of breast cancer cells via modulation of akt activity and p27 level,” Phytotherapy Research, vol. 24, no. 2, pp. 198–204, 2010. View at Publisher · View at Google Scholar · View at Scopus
  91. L. Wang, Y. Ling, Y. Chen et al., “Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells,” Cancer Letters, vol. 297, no. 1, pp. 42–48, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. B. A. Pockaj, C. L. Loprinzi, J. A. Sloan et al., “Pilot evaluation of black cohosh for the treatment of hot flashes in women,” Cancer Investigation, vol. 22, no. 4, pp. 515–521, 2004. View at Publisher · View at Google Scholar · View at Scopus
  93. V. C. K. Wong, C. E. D. Lim, X. Luo, and W. S. F. Wong, “Current alternative and complementary therapies used in menopause,” Gynecological Endocrinology, vol. 25, no. 3, pp. 166–174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  94. C. Rotem and B. Kaplan, “Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study,” Gynecological Endocrinology, vol. 23, no. 2, pp. 117–122, 2007. View at Publisher · View at Google Scholar · View at Scopus
  95. A. Sammartino, G. A. Tommaselli, V. Gargano, C. Di Carlo, W. Attianese, and C. Nappi, “Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial,” Gynecological Endocrinology, vol. 22, no. 11, pp. 646–650, 2006. View at Publisher · View at Google Scholar · View at Scopus
  96. N. Morabito, A. Crisafulli, C. Vergara et al., “Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study,” Journal of Bone and Mineral Research, vol. 17, no. 10, pp. 1904–1912, 2002. View at Google Scholar · View at Scopus
  97. M. Rhyu, J. Lu, D. E. Webster, D. S. Fabricant, N. R. Farnsworth, and Z. J. Wang, “Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human μ opiate receptor,” Journal of Agricultural and Food Chemistry, vol. 54, no. 26, pp. 9852–9857, 2006. View at Publisher · View at Google Scholar · View at Scopus
  98. S. Frei-Kleiner, W. Schaffner, V. W. Rahlfs, C. Bodmer, and M. Birkhäuser, “Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial,” Maturitas, vol. 51, no. 4, pp. 397–404, 2005. View at Publisher · View at Google Scholar · View at Scopus
  99. K. M. Newton, S. D. Reed, A. Z. LaCroix, L. C. Grothaus, K. Ehrlich, and J. Guiltinan, “Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial,” Annals of Internal Medicine, vol. 145, no. 12, pp. 869–879, 2006. View at Google Scholar · View at Scopus
  100. M. D. J. Molla, J. J. Hidalgo-Mora, and M. G. Soteras, “Phytotherapy as alternative to hormone replacement therapy,” Frontiers in Bioscience, vol. 3, pp. 191–204, 2011. View at Google Scholar · View at Scopus
  101. J. X. Liu, J. Y. Zhou, and T. F. Liu, “Phase III clinical trial for Yun Zhi polysaccharide (PSP) capsules,” in Advanced Research in PSP, Q. Y. Yang, Ed., pp. 295–303, Hong Kong Association for Health Care, Hong Kong, China, 1999. View at Google Scholar
  102. T. W. Sun and Y. P. Zhu, “The effect of PSP on immune function and living quality in patients receiving chemotherapy for gynecological malignancies,” in Advanced Research in PSP, Q. Y. Yang, Ed., pp. 308–329, Hong Kong Association for Health Care, Hong Kong, China, 1999. View at Google Scholar
  103. W. L. Y. Eliza, C. K. Fai, and L. P. Chung, “Efficacy of Yun Zhi (coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis,” Recent Patents on Inflammation and Allergy Drug Discovery, vol. 6, no. 1, pp. 78–87, 2012. View at Publisher · View at Google Scholar · View at Scopus
  104. Z. Pang, Y. Chen, and M. Zhou, “Polysaccharide Krestin Enhances Manganese Superoxide Dismutase Activity and mRNA Expression in Mouse Peritoneal Macrophages,” American Journal of Chinese Medicine, vol. 28, no. 3-4, pp. 331–341, 2000. View at Google Scholar · View at Scopus
  105. M. Fisher and L. Yang, “Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy,” Anticancer Research, vol. 22, no. 3, pp. 1737–1754, 2002. View at Google Scholar · View at Scopus
  106. S. Kudo, J. Tanaka, H. Kashida, Y. Tamegai, S. Endo, and H. Yamano, “Effectiveness of immunochemotherapy with PSK, a protein-bound polysaccharide, in colorectal cancer and changes of tumor marker,” Oncology reports, vol. 9, no. 3, pp. 635–638, 2002. View at Google Scholar · View at Scopus
  107. S. Bokmand and S. Flyger, “Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study,” Breast, vol. 22, no. 3, pp. 320–323, 2013. View at Publisher · View at Google Scholar
  108. J. L. Otte, J. S. Carpenter, X. Zhong, and P. A. S. Johnstone, “Feasibility study of acupuncture for reducing sleep disturbances and hot flashes in postmenopausal breast cancer survivors,” Clinical Nurse Specialist, vol. 25, no. 5, pp. 228–236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  109. A. Liljegren, P. Gunnarsson, B. Landgren, N. Robéus, H. Johansson, and S. Rotstein, “Reducing vasomotor symptoms with acupuncture in breast cancer patients treated with adjuvant tamoxifen: a randomized controlled trial,” Breast Cancer Research and Treatment, pp. 1–8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  110. B. A. De Valois, T. E. Young, N. Robinson, C. McCourt, and E. J. Maher, “Using traditional acupuncture for breast cancer-related hot flashes and night sweats,” Journal of Alternative and Complementary Medicine, vol. 16, no. 10, pp. 1047–1057, 2010. View at Publisher · View at Google Scholar · View at Scopus
  111. J. Hervik and O. Mjåland, “Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial,” Breast Cancer Research and Treatment, vol. 116, no. 2, pp. 311–316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  112. J. Frisk, S. Carlhäll, A.-C. Källström, L. Lindh-Åstrand, A. Malmström, and M. Hammar, “Long-term follow-up of acupuncture and hormone therapy on hot flushes in women with breast cancer: a prospective, randomized, controlled multicenter trial,” Climacteric, vol. 11, no. 2, pp. 166–174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  113. G. Deng, A. Vickers, S. Yeung, and B. Cassileth, “Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients,” Journal of Clinical Oncology, vol. 25, no. 35, pp. 5584–5590, 2007. View at Publisher · View at Google Scholar · View at Scopus
  114. E. Nedstrand, Y. Wyon, M. Hammar, and K. Wijma, “Psychological well-being improves in women with breast cancer after treatment with applied relaxation or electro-acupuncture for vasomotor symptom,” Journal of Psychosomatic Obstetrics and Gynecology, vol. 27, no. 4, pp. 193–199, 2006. View at Publisher · View at Google Scholar · View at Scopus
  115. J. S. Carpenter, N. Wells, B. Lambert et al., “A pilot study of magnetic therapy for hot flashes after breast cancer,” Cancer Nursing, vol. 25, no. 2, pp. 104–109, 2002. View at Google Scholar · View at Scopus
  116. G. Porzio, T. Trapasso, S. Martelli et al., “Acupuncture in the treatment of menopause-related symptoms in women taking tamoxifen,” Tumori, vol. 88, no. 2, pp. 128–130, 2002. View at Google Scholar · View at Scopus
  117. S. Choo, K. Kong, W. Lim, F. Gao, K. Chua, and S. Leong, “Electroacupuncture for refractory acute emesis caused by chemotherapy,” Journal of Alternative and Complementary Medicine, vol. 12, no. 10, pp. 963–969, 2006. View at Publisher · View at Google Scholar · View at Scopus
  118. S. L. Dibble, J. Luce, B. A. Cooper et al., “Acupressure for chemotherapy-induced nausea and vomiting: a randomized clinical trial,” Oncology Nursing Forum, vol. 34, no. 4, pp. 813–820, 2007. View at Publisher · View at Google Scholar · View at Scopus
  119. A. Molassiotis, A. M. Helin, R. Dabbour, and S. Hummerston, “The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients,” Complementary Therapies in Medicine, vol. 15, no. 1, pp. 3–12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  120. S. L. Dibble, J. Chapman, K. A. Mack, and A. S. Shih, “Acupressure for nausea: results of a pilot study,” Oncology Nursing Forum, vol. 27, no. 1, pp. 41–47, 2000. View at Google Scholar · View at Scopus
  121. J. Shen, N. Wenger, J. Glaspy et al., “Electroacupuncture for control of myeloablative chemotherapy-induced emesis: a randomized controlled trial,” Journal of the American Medical Association, vol. 284, no. 21, pp. 2755–2761, 2000. View at Google Scholar · View at Scopus
  122. S. Gu, J. Yang, and M. Zhang, “Contrast study for the effects of different administration route of dexamethasone on gastrointestinal reaction induced by chemotherapy,” Journal of Nurses Training, vol. 22, no. 5, pp. 399–400, 2007. View at Google Scholar
  123. Y. F. Ho, “Acupressure and psychological intervention for emesis due to chemotherapy on the patients with mammary cancer,” Guangxi Medical Journal, vol. 28, no. 5, pp. 738–739, 2006. View at Google Scholar
  124. Y. Xu, J. L. Wang, and H. Y. Du, “Contrast observation on injection metoclopramide in acupuncture point for the treatment of emesis after chemical treatment to 100 patients with cancer,” Central Plains Medical Journal, vol. 32, no. 15, p. 58, 2005. View at Google Scholar
  125. C. H. Ning, “Contrast observation on injection metoclopramide in different acupuncture point for the treatment of emesis after chemical treatment to mammary cancer,” Hunan Guiding Journal of Traditional Chinese Medicine, vol. 10, no. 2, pp. 39–41, 2004. View at Google Scholar
  126. E. Nystrom, G. Ridderstrom, and A. Leffler, “Manual acupuncture as an adjunctive treatment of nausea in patients with cancer in palliative care—a prospective, observational pilot study,” Acupuncture in Medicine, vol. 26, no. 1, pp. 27–32, 2008. View at Google Scholar · View at Scopus
  127. W. E. Mehling, B. Jacobs, M. Acree et al., “Symptom management with massage and acupuncture in postoperative Cancer patients: a randomized controlled trial,” Journal of Pain and Symptom Management, vol. 33, no. 3, pp. 258–266, 2007. View at Publisher · View at Google Scholar · View at Scopus
  128. J. Liang, L. P. Wang, and G. N. Wang, “The effect of preemptive HAN'S acupoint nerve stimulator on postoperative pain in patients undergoing radical mastectomy,” Journal of Harbin Medical University, vol. 41, no. 6, pp. 607–609, 2007. View at Google Scholar
  129. J. P. He, M. Friedrich, A. K. Ertan, K. Müller, and W. Schmidt, “Pain-relief and movement improvement by acupuncture after ablation and axillary lymphadenectomy in patients with mammary cancer,” Clinical and Experimental Obstetrics and Gynecology, vol. 26, no. 2, pp. 81–84, 1999. View at Publisher · View at Google Scholar · View at Scopus
  130. T. Bao, L. Cai, J. T. Giles et al., “A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors,” Breast Cancer Research and Treatment, vol. 138, no. 1, pp. 167–174, 2013. View at Publisher · View at Google Scholar
  131. K. D. Crew, J. L. Capodice, H. Greenlee et al., “Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer,” Journal of Clinical Oncology, vol. 28, no. 7, pp. 1154–1160, 2010. View at Publisher · View at Google Scholar · View at Scopus
  132. J. J. Mao, D. W. Bruner, C. Stricker et al., “Feasibility trial of electroacupuncture for aromatase inhibitor-related arthralgia in breast cancer survivors,” Integrative Cancer Therapies, vol. 8, no. 2, pp. 123–129, 2009. View at Publisher · View at Google Scholar · View at Scopus
  133. B. R. Cassileth, K. J. Van Zee, Y. Chan et al., “A safety and efficacy pilot study of acupuncture for the treatment of chronic lymphoedema,” Acupuncture in Medicine, vol. 29, no. 3, pp. 170–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  134. M. Alem and M. S. C. Gurgel, “Acupuncture in the rehabilitation of women after breast cancer surgery—a case series,” Acupuncture in Medicine, vol. 26, no. 2, pp. 86–93, 2008. View at Google Scholar · View at Scopus
  135. S. T. Sun, G. Y. Nan, and Y. L. Lee, “Observation on injection g-csf in acupuncture point for the treatment of leukopenia after chemical treatment to 102 patients with mammary cancer,” World Health Digest Journal of New Medicine, vol. 4, no. 6, p. 50, 2007. View at Google Scholar
  136. B. Y. Chang and B. H. Lian, “Observation on injection in acupuncture point for the treatment of leukopenia after chemical treatment to 45 patients with cancer,” Journal of Practical and Traditional Chinese Medicine, vol. 18, no. 2, p. 30, 2002. View at Google Scholar
  137. K. W. Tsang, C. L. Lam, C. Yan et al., “coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer,” Respiratory Medicine, vol. 97, no. 6, pp. 618–624, 2003. View at Publisher · View at Google Scholar · View at Scopus
  138. M. Fisher and L. Yang, “Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy,” Anticancer Research, vol. 22, no. 3, pp. 1737–1754, 2002. View at Google Scholar · View at Scopus
  139. P. M. Kidd, “The use of mushroom glucans and proteoglycans in cancer treatment,” Alternative Medicine Review, vol. 5, no. 1, pp. 4–27, 2000. View at Google Scholar · View at Scopus
  140. J. W. M. Yuen and M. D. I. Gohel, “Anticancer effects of Ganoderma lucidum: a review of scientific evidence,” Nutrition and Cancer, vol. 53, no. 1, pp. 11–17, 2005. View at Publisher · View at Google Scholar · View at Scopus
  141. H. Zhao, Q. Zhang, L. Zhao, X. Huang, J. Wang, and X. Kang, “Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: a pilot clinical trial,” Evidence-based Complementary and Alternative Medicine, vol. 2012, Article ID 809614, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  142. Z. Xu, X. Chen, Z. Zhong, L. Chen, and Y. Wang, “Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities,” American Journal of Chinese Medicine, vol. 39, no. 1, pp. 15–27, 2011. View at Publisher · View at Google Scholar · View at Scopus
  143. C. Weng and G. Yen, “The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis,” Clinical and Experimental Metastasis, vol. 27, no. 5, pp. 361–369, 2010. View at Publisher · View at Google Scholar · View at Scopus
  144. G. Wu, J. Lu, J. Guo et al., “Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells,” Fitoterapia, vol. 83, no. 2, pp. 408–414, 2012. View at Publisher · View at Google Scholar · View at Scopus
  145. P. P. Bao, W. Lu, Y. Cui et al., “Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study,” PLoS One, vol. 7, no. 6, Article ID e39343.
  146. C. I. Coleman, J. H. Hebert, and P. Reddy, “The effects of Panax ginseng on quality of life,” Journal of Clinical Pharmacy and Therapeutics, vol. 28, no. 1, pp. 5–15, 2003. View at Publisher · View at Google Scholar · View at Scopus
  147. Y. Cui, X. Shu, Y. Gao, H. Cai, M. Tao, and W. Zheng, “Association of ginseng use with survival and quality of life among breast cancer patients,” American Journal of Epidemiology, vol. 163, no. 7, pp. 645–653, 2006. View at Publisher · View at Google Scholar · View at Scopus
  148. B. K. Vogler, M. H. Pittler, and E. Ernst, “The efficacy of ginseng. A systematic review of randomised clinical trials,” European Journal of Clinical Pharmacology, vol. 55, no. 8, pp. 567–575, 1999. View at Publisher · View at Google Scholar · View at Scopus
  149. W. Lu, Y. Cui, Y. Zheng et al., “Impact of newly diagnosed breast cancer on quality of life among Chinese women,” Breast Cancer Research and Treatment, vol. 102, no. 2, pp. 201–210, 2007. View at Publisher · View at Google Scholar · View at Scopus
  150. A. H. Wu, M. C. Yu, C. Tseng, J. Hankin, and M. C. Pike, “Green tea and risk of breast cancer in Asian Americans,” International Journal of Cancer, vol. 106, no. 4, pp. 574–579, 2003. View at Publisher · View at Google Scholar · View at Scopus
  151. A. H. Wu, D. Spicer, F. Z. Stanczyk, C. Tseng, C. S. Yang, and M. C. Pike, “Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women,” Cancer Prevention Research, vol. 5, no. 3, pp. 393–402, 2012. View at Publisher · View at Google Scholar · View at Scopus
  152. N. R. Stendell-Hollis, C. A. Thomson, P. A. Thompson, J. W. Bea, E. C. Cussler, and I. A. Hakim, “Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors,” Journal of Human Nutrition and Dietetics, vol. 23, no. 6, pp. 590–600, 2010. View at Publisher · View at Google Scholar · View at Scopus
  153. T. Luo, J. Wang, Y. Yin et al., “(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma,” Breast Cancer Research, vol. 12, no. 1, article R8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  154. J. J. Dignam, K. Wieand, K. A. Johnson et al., “Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer,” Breast Cancer Research and Treatment, vol. 97, no. 3, pp. 245–254, 2006. View at Publisher · View at Google Scholar · View at Scopus
  155. J. Eisenbraun, R. Scheer, M. Kröz, F. Schad, and R. Huber, “Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract,” Phytomedicine, vol. 18, no. 2-3, pp. 151–157, 2011. View at Publisher · View at Google Scholar · View at Scopus
  156. M. A. Horneber, G. Bueschel, R. Huber, K. Linde, and M. Rostock, “Mistletoe therapy in oncology,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD003297, 2008. View at Publisher · View at Google Scholar · View at Scopus
  157. J. Beuth, B. Schneider, and J. M. Schierholz, “Impact of complementary treatment of breast cancer patients with standardized mistletoe extract during aftercare: a controlled multicenter comparative Epidemiological Cohort Study,” Anticancer Research, vol. 28, no. 1B, pp. 523–527, 2008. View at Google Scholar · View at Scopus
  158. A. Büssing, C. Stumpf, W. Tröger, and M. Schietzel, “Course of mitogen-stimulated T lymphocytes in cancer patients treated with Viscum album extracts,” Anticancer Research, vol. 27, no. 4C, pp. 2903–2910, 2007. View at Google Scholar · View at Scopus
  159. J. Eggenschwiler, A. Patrignani, U. Wagner et al., “Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro,” Arzneimittel-Forschung, vol. 56, no. 6A, pp. 483–496, 2006. View at Google Scholar · View at Scopus
  160. V. Bocci, “Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review,” Journal of Biological Regulators and Homeostatic Agents, vol. 7, no. 1, pp. 1–6, 1993. View at Google Scholar · View at Scopus
  161. V. F. Semiglazov, V. V. Stepula, A. Dudov, J. Schnitker, and U. Mengs, “Quality of life is improved in breast cancer patients by standardised mistletoe extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial,” Anticancer Research, vol. 26, no. 2B, pp. 1519–1529, 2006. View at Google Scholar · View at Scopus
  162. V. F. Semiglasov, V. V. Stepula, A. Dudov, W. Lehmacher, and U. Mengs, “The standardised mistletoe extract PS76A2 improves QoL in patients with breast Cancer Receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial,” Anticancer Research, vol. 24, no. 2C, pp. 1293–1302, 2004. View at Google Scholar · View at Scopus
  163. P. Fritz, J. Dippon, T. Kierschke et al., “Impact of mistletoe lectin binding in Breast Cancer,” Anticancer Research, vol. 24, no. 2C, pp. 1187–1192, 2004. View at Google Scholar · View at Scopus
  164. S. Johansson, J. Gullbo, P. Lindholm et al., “Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells,” Cellular and Molecular Life Sciences, vol. 60, no. 1, pp. 165–175, 2003. View at Publisher · View at Google Scholar · View at Scopus
  165. A. Büssing, W. Tröger, C. Stumpf, and M. Schietzel, “Local reactions to treatments with Viscum album L. extracts and their association with T-lymphocyte subsets and quality of life,” Anticancer Research, vol. 28, no. 3B, pp. 1893–1897, 2008. View at Google Scholar · View at Scopus
  166. W. T. Y. Loo, L. Jin, L. W. C. Chow, M. N. B. Cheung, and M. Wang, “Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients,” Expert Opinion on Investigational Drugs, vol. 19, no. 1, pp. S91–S100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  167. M. Abidov, S. Grachev, R. D. Seifulla, and T. N. Ziegenfuss, “Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood,” Bulletin of Experimental Biology and Medicine, vol. 138, no. 1, pp. 63–64, 2004. View at Publisher · View at Google Scholar · View at Scopus
  168. O. A. Bocharova, B. P. Matveev, A. I. Baryshnikov, K. M. Figurin, R. V. Serebriakova, and N. B. Bodrova, “The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research),” Urologiya i Nefrologiya, no. 2, pp. 46–47, 1995. View at Google Scholar · View at Scopus
  169. M. J. Campbell, B. Hamilton, M. Shoemaker, M. Tagliaferri, I. Cohen, and D. Tripathy, “Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro,” Anticancer Research, vol. 22, no. 6C, pp. 3843–3852, 2002. View at Google Scholar · View at Scopus
  170. M. Shoemaker, B. Hamilton, S. H. Dairkee, I. Cohen, and M. J. Campbell, “In vitro anticancer activity of twelve Chinese medicinal herbs,” Phytotherapy Research, vol. 19, no. 7, pp. 649–651, 2005. View at Publisher · View at Google Scholar · View at Scopus
  171. S. Fong, M. Shoemaker, J. Cadaoas et al., “Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells,” Cancer Biology and Therapy, vol. 7, no. 4, pp. 577–586, 2008. View at Google Scholar · View at Scopus
  172. A. T. Perez, B. Arun, D. Tripathy et al., “A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer,” Breast Cancer Research and Treatment, vol. 120, no. 1, pp. 111–118, 2010. View at Publisher · View at Google Scholar · View at Scopus
  173. J. Klawitter, J. Klawitter, J. Gurshtein et al., “Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study,” International Journal of Cancer, vol. 129, no. 12, pp. 2945–2957, 2011. View at Publisher · View at Google Scholar · View at Scopus
  174. B. B. Aggarwal, “Targeting lammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals,” Annual Review of Nutrition, vol. 30, pp. 173–199, 2010. View at Publisher · View at Google Scholar · View at Scopus
  175. V. P. Menon and A. R. Sudheer, “Antioxidant and anti-inflammatory properties of curcumin,” Advances in Experimental Medicine and Biology, vol. 595, pp. 105–125, 2007. View at Publisher · View at Google Scholar · View at Scopus
  176. A. Goel and B. B. Aggarwal, “Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs,” Nutrition and Cancer, vol. 62, no. 7, pp. 919–930, 2010. View at Publisher · View at Google Scholar · View at Scopus
  177. M. Jiang, O. Huang, X. Zhang et al., “Curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9,” Molecules, vol. 18, no. 1, pp. 701–720, 2013. View at Google Scholar
  178. M. Bayet-Robert, F. Kwiatkowski, M. Leheurteur et al., “Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer,” Cancer Biology and Therapy, vol. 9, no. 1, 2010. View at Google Scholar · View at Scopus
  179. K. Mehta, P. Pantazis, T. McQueen, and B. B. Aggarwal, “Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines,” Anti-Cancer Drugs, vol. 8, no. 5, pp. 470–481, 1997. View at Google Scholar · View at Scopus
  180. A. Shehzad, S. Khan, and Y. Sup Lee, “Curcumin molecular targets in obesity and obesity-related cancers,” Future Oncology, vol. 8, no. 2, pp. 179–190, 2012. View at Publisher · View at Google Scholar · View at Scopus
  181. P. Anand, C. Sundaram, S. Jhurani, A. B. Kunnumakkara, and B. B. Aggarwal, “Curcumin and cancer: an “old-age” disease with an “age-old” solution,” Cancer Letters, vol. 267, no. 1, pp. 133–164, 2008. View at Publisher · View at Google Scholar · View at Scopus
  182. M. R. C. Schetinger, I. L. G. Farias, M. C. S. Araújo et al., “Uncaria tomentosa for reducing side effects caused by chemotherapy in CRC patients: clinical trial,” Evidence-based Complementary and Alternative Medicine, vol. 2012, Article ID 892182, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  183. Y. Sheng, R. W. Pero, and H. Wagner, “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa,” Phytomedicine, vol. 7, no. 2, pp. 137–143, 2000. View at Google Scholar · View at Scopus
  184. M. Wurm, L. Kacani, G. Laus, K. Keplinger, and M. P. Dierich, “Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor,” Planta Medica, vol. 64, no. 8, pp. 701–704, 1998. View at Publisher · View at Google Scholar · View at Scopus
  185. L. Allen-Hall, P. Cano, J. T. Arnason, R. Rojas, O. Lock, and R. M. Lafrenie, “Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1β and TNF-α,” Journal of Ethnopharmacology, vol. 109, no. 2, pp. 312–317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  186. R. Pilarski, H. Zieliński, D. Ciesiołka, and K. Gulewicz, “Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 18–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  187. L. Riva, D. Coradini, G. Di Fronzo et al., “The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line,” Anticancer Research, vol. 21, no. 4A, pp. 2457–2461, 2001. View at Google Scholar · View at Scopus
  188. L. Huai, M. Broffman, and S. Pei, “A Comprehensive Textbook,” in China Acupuncture and Moxibustion Supplies, Taipei, Taiwan, 1976. View at Google Scholar
  189. Shanghai College of Traditional Medicine, Acupuncture. A Comprehensive Text, Eastland, Seattle, Wash, USA, 1987.
  190. Beijing Shanghai aNCoTCM, Essentials of Chinese Acupuncture, Foreign Language Press, Beijing, China, 1980.
  191. S. Schroeder, G. Meyer-Hamme, J. Zhang, S. Epplée, T. Friedemann, and W. Hu, “An acupuncture research protocol developed from historical writings by mathematical reflections: a rational individualized acupoint selection method for immediate pain relief,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 256754, 16 pages, 2013. View at Publisher · View at Google Scholar
  192. A. Ellis, N. Wiseman, and K. Boss, Fundamentals of Chinese Acupuncture,, Paradigm, Brookline, Mass, USA, 1991.
  193. J. Zhang, B. X. Zhao, and X. L. Lao, Acupuncture and Moxibustion, People's Medical Publising House, Beijing, China, 2004.
  194. H. Guo, J. Tian, X. Wang, Y. Fang, Y. Hou, and J. Han, “Brain substrates activated by electroacupuncture of different frequencies (I): comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides,” Molecular Brain Research, vol. 43, no. 1-2, pp. 157–166, 1996. View at Publisher · View at Google Scholar · View at Scopus
  195. J.-H. Lee and A. J. Beitz, “The distrubution of brain-stem and spinal cord nuclei associated with different frequencies of electroacupuncture analgesia,” Pain, vol. 52, no. 1, pp. 11–28, 1993. View at Publisher · View at Google Scholar · View at Scopus
  196. J. Filshie and J. W. Thompson, “Acupuncture,” in The Oxford Textbook of Palliative Medicine, G. Hanks, N. I. Cherny, N. A. Christakis et al., Eds., pp. 772–778, Oxford University Press, 4th edition, 2009. View at Google Scholar
  197. J. S. Han and L. Terenius, “Neurochemical basis of acupuncture analgesia,” Annual Review of Pharmacology and Toxicology, vol. 22, pp. 193–220, 1982. View at Google Scholar · View at Scopus
  198. K. Uvnäs-Moberg, “Physiological and endocrine effects of social contact,” Annals of the New York Academy of Sciences, vol. 807, pp. 146–163, 1997. View at Publisher · View at Google Scholar · View at Scopus
  199. L. U. Roth, A. Maret-Maric, R. H. Adler, and B. E. Neuenschwander, “Acupuncture points have subjective (needing sensation) and objective (serum cortisol increase) specificity,” Acupuncture in Medicine, vol. 15, no. 1, pp. 2–5, 1997. View at Google Scholar · View at Scopus
  200. W. Zhang, Z. Jin, G. Cui et al., “Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study,” Brain Research, vol. 982, no. 2, pp. 168–178, 2003. View at Publisher · View at Google Scholar · View at Scopus
  201. J. Pariente, P. White, R. S. J. Frackowiak, and G. Lewith, “Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture,” NeuroImage, vol. 25, no. 4, pp. 1161–1167, 2005. View at Publisher · View at Google Scholar · View at Scopus
  202. A. White, M. Cummings, and J. Filshie, An Introduction to Western Medical Acupuncture, Churchill Livingstone, 1st edition, 2008.
  203. Y. J. Jeong, Y. S. Park, H. J. Kwon, I. H. Shin, J. G. Bong, and S. H. Park, “Acupuncturefor the treatment of hot flashes in patients with Breast Cancer receiving antiestrogen therapy: a pilot study in Korean women,” Journal of Alternative and Complementary Medicine, 2013. View at Publisher · View at Google Scholar
  204. J. Filshie, T. Bolton, D. Browne, and S. Ashley, “Acupuncture and self acupuncture for long term treatment of vasomotor symptoms in cancer patients - Audit and treatment algorithm,” Acupuncture in Medicine, vol. 23, no. 4, pp. 171–180, 2005. View at Publisher · View at Google Scholar · View at Scopus
  205. J. Filshie and J. Hester, “Guidelines for providing acupuncture treatment for cancer patients - A peer-reviewed sample policy document,” Acupuncture in Medicine, vol. 24, no. 4, pp. 172–182, 2006. View at Google Scholar · View at Scopus
  206. J. M. Ezzo, M. A. Richardson, A. Vickers et al., “Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD002285, 2006. View at Google Scholar · View at Scopus
  207. M. H. J. van den Beuken-van Everdingen, J. M. de Rijke, A. G. Kessels, H. C. Schouten, M. van Kleef, and J. Patijn, “Prevalence of pain in patients with cancer: a systematic review of the past 40 years,” Annals of Oncology, vol. 18, no. 9, pp. 1437–1449, 2007. View at Publisher · View at Google Scholar · View at Scopus
  208. C. A. Paley, M. I. Bennett, and M. I. Johnson, “Acupuncture for cancer-induced bone pain?” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 671043, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  209. C. A. Paley, M. I. Johnson, O. A. Tashani, and A. Bagnall, “Acupuncture for cancer pain in adults,” Cochrane Database of Systematic Reviews, vol. 1, Article ID CD007753, 2011. View at Google Scholar · View at Scopus
  210. K. D. Crew, J. L. Capodice, H. Greenlee et al., “Pilot study of acupuncture for the treatment of joint symptoms related to adjuvant aromatase inhibitor therapy in postmenopausal breast cancer patients,” Journal of Cancer Survivorship, vol. 1, no. 4, pp. 283–291, 2007. View at Publisher · View at Google Scholar · View at Scopus
  211. O. Minton, A. Richardson, M. Sharpe, M. Hotopf, and P. Stone, “A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue,” Journal of the National Cancer Institute, vol. 100, no. 16, pp. 1155–1166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  212. A. J. Vickers, D. J. Straus, B. Fearon, and B. R. Cassileth, “Acupuncture for postchemotherapy fatigue: a phase II study,” Journal of Clinical Oncology, vol. 22, no. 9, pp. 1731–1735, 2004. View at Publisher · View at Google Scholar · View at Scopus
  213. C. Smith, B. Carmady, C. Thornton, J. Perz, and J. M. Ussher, “The effect of acupuncture on post-cancer fatigue and well-being for women recovering from breast cancer: a pilot randomised controlled trial,” Medical Acupuncture, vol. 31, no. 1, pp. 9–15, 2013. View at Google Scholar
  214. Molassiotis, J. Bardy, J. Finnegan-John et al., “Acupuncture for cancer-related fatigue in patients with breast cancer: a pragmatic randomized controlled trial,” Journal of Clinical Oncology, vol. 30, no. 36, pp. 4470–4476, 2012. View at Google Scholar
  215. M. F. Johnston, R. D. Hays, S. K. Subramanian et al., “Patient education integrated with acupuncture for relief of cancer-related fatigue randomized controlled feasibility study,” BMC Complementary and Alternative Medicine, vol. 11, article 49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  216. A. Molassiotis, P. Sylt, and H. Diggins, “The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial,” Complementary Therapies in Medicine, vol. 15, no. 4, pp. 228–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
  217. R. J. Leo and J. S. A. Ligot Jr., “A systematic review of randomized controlled trials of acupuncture in the treatment of depression,” Journal of Affective Disorders, vol. 97, no. 1–3, pp. 13–22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  218. D. Duan, Y. Tu, L. Chen, and Z. Wu, “Efficacy evaluation for depression with somatic symptoms treated by electroacupuncture combined with fluoxetine,” Journal of Traditional Chinese Medicine, vol. 29, no. 3, pp. 167–173, 2009. View at Google Scholar · View at Scopus
  219. E. M. Walker, A. I. Rodriguez, B. Kohn et al., “Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial,” Journal of Clinical Oncology, vol. 28, no. 4, pp. 634–640, 2010. View at Publisher · View at Google Scholar · View at Scopus
  220. W. E. Mehling, B. Jacobs, M. Acree et al., “Symptom management with massage and acupuncture in postoperative Cancer patients: a randomized controlled trial,” Journal of Pain and Symptom Management, vol. 33, no. 3, pp. 258–266, 2007. View at Publisher · View at Google Scholar · View at Scopus
  221. Y. C. Hai, Y. Shi, S. N. Chi, M. C. Sai, K. K. L. Yung, and L. Z. Qing, “Auricular acupuncture treatment for insomnia: a systematic review,” Journal of Alternative and Complementary Medicine, vol. 13, no. 6, pp. 669–676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  222. D. K. Cheuk, W. F. Yeung, K. F. Chung, and V. Wong, “Acupuncture for insomnia,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD005472, 2007. View at Google Scholar · View at Scopus
  223. J. L. Otte, J. S. Carpenter, X. Zhong, and P. A. S. Johnstone, “Feasibility study of acupuncture for reducing sleep disturbances and hot flashes in postmenopausal breast cancer survivors,” Clinical Nurse Specialist, vol. 25, no. 5, pp. 228–236, 2011. View at Publisher · View at Google Scholar · View at Scopus
  224. J. E. Harrington, B. S. Baker, and C. J. Hoffman, “Effect of an integrated support programme on the concerns and wellbeing of women with breast cancer: a national service evaluation,” Complementary Therapies in Clinical Practice, vol. 18, no. 1, pp. 10–15, 2012. View at Publisher · View at Google Scholar · View at Scopus
  225. J. Frisk, A. Källström, N. Wall, M. Fredrikson, and M. Hammar, “Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes,” Supportive Care in Cancer, pp. 1–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  226. J. Hervik and O. Mjåland, “Quality of life of breast cancer patients medicated with anti-estrogens, 2 years after acupuncture treatment: a qualitative study,” International Journal of Women's Health, vol. 2, no. 1, pp. 319–325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  227. E. Dean-Clower, A. M. Doherty-Gilman, A. Keshaviah et al., “Acupuncture as palliative therapy for physical symptoms and quality of life for advanced cancer patients,” Integrative Cancer Therapies, vol. 9, no. 2, pp. 158–167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  228. W. Lu, D. Hu, E. Dean-Clower et al., “Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials,” Journal of the Society for Integrative Oncology, vol. 5, no. 1, pp. 1–10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  229. A. White, “A cumulative review of the range and incidence of significant adverse events associated with acupuncture,” Acupuncture in Medicine, vol. 22, no. 3, pp. 122–133, 2004. View at Google Scholar · View at Scopus
  230. G. Ernst, H. Strzyz, and H. Hagmeister, “Incidence of adverse effects during acupuncture therapy—a multicentre survey,” Complementary Therapies in Medicine, vol. 11, no. 2, pp. 93–97, 2003. View at Publisher · View at Google Scholar · View at Scopus
  231. A. White, S. Hayhoe, A. Hart, and E. Ernst, “Adverse events following acupuncture: prospective survey of 32 000 consultations with doctors and physiotherapists,” British Medical Journal, vol. 323, no. 7311, pp. 485–486, 2001. View at Google Scholar · View at Scopus
  232. D. Melchart, W. Weidenhammer, A. Streng et al., “Prospective investigation of adverse effects of acupuncture in 97 733 patients,” Archives of Internal Medicine, vol. 164, no. 1, pp. 104–105, 2004. View at Publisher · View at Google Scholar · View at Scopus
  233. A. Vickers and C. Zollman, “ABC of complementary medicine: acupuncture,” British Medical Journal, vol. 319, no. 7215, pp. 973–976, 1999. View at Google Scholar · View at Scopus
  234. S. M. Sagar, “Acupuncture as an evidence-based option for symptom control in cancer patients,” Current Treatment Options in Oncology, vol. 9, no. 2-3, pp. 117–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  235. C. M. Witt, D. Pach, B. Brinkhaus et al., “Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form,” Forschende Komplementarmedizin, vol. 16, no. 2, pp. 91–97, 2009. View at Publisher · View at Google Scholar · View at Scopus
  236. W. Lu, E. Dean-Clower, A. Doherty-Gilman, and D. S. Rosenthal, “The value of acupuncture in Cancer care,” Hematology/Oncology Clinics of North America, vol. 22, no. 4, pp. 631–648, 2008. View at Publisher · View at Google Scholar · View at Scopus
  237. E. Tukmachi, “Treatment of hot flushes in breast cancer patients with acupuncture,” Acupuncture in Medicine, vol. 18, no. 1, pp. 22–27, 2000. View at Google Scholar · View at Scopus
  238. W. Lu and D. S. Rosenthal, “Recent advances in oncology acupuncture and safety considerations in practice,” Current Treatment Options in Oncology, vol. 11, no. 3-4, pp. 141–146, 2010. View at Publisher · View at Google Scholar · View at Scopus