Inhibition of Acute Phase Inflammation by Laminaria japonica through Regulation of iNOS-NF-κB Pathway

Figure 1

Inhibition of carrageenan-induced paw edema formation by the ethanol extract of Laminaria japonica (LJE). LJE was administered for 3 days to rats at the oral dose of 0.1 or 0.3 g kg⁻¹ day⁻¹ prior to the induction of paw edema. Paw edema was induced by subcutaneously injecting a 1% solution of carrageenan dissolved in saline (0.1 mL per animal) into the hind paw. The thickness of the paw was measured before and 1–4 h after carrageenan injection. Data point represents the swelling volume of the paw, which was standardized with the thickness of the paw volume before carrageenan injection. Dexamethasone (Dex, 1 mg kg⁻¹, p.o.) was used as a positive control. Data represents the mean ± S.E.M. of six animals (significant as compared with carrageenan alone, ^∗𝑃<0.05, ^∗∗𝑃<0.01).