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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 454389, 9 pages
http://dx.doi.org/10.1155/2013/454389
Research Article

Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes Apoptosis In Vitro and In Vivo

1Fujian Academy of Traditional Chinese Medicine, Fuzhou, Fujian 350003, China
2Obstetrics & Gynecology Hospital of Fudan University, Shanghai 200090, China
3Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China

Received 10 January 2013; Revised 30 September 2013; Accepted 7 October 2013

Academic Editor: Myeong Soo Lee

Copyright © 2013 Xiu-feng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. J. Geng, Y. Ishikawa, D. E. Vatner et al., “Apoptosis of cardiac myocytes in Gsα transgenic mice,” Circulation Research, vol. 84, no. 1, pp. 34–42, 1999. View at Google Scholar · View at Scopus
  2. P. Krishnamurthy, V. Subramanian, M. Singh, and K. Singh, “β1 integrins modulate β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling,” Hypertension, vol. 49, no. 4, pp. 865–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. T. Jin, N. Hasebe, T. Matsusaka et al., “Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and β-adrenergic desensitization,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 292, no. 3, pp. H1593–H1599, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. G. C. Fan, Q. Yuan, G. Song et al., “Small heat-shock protein Hsp20 attenuates β-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1,” Circulation Research, vol. 99, no. 11, pp. 1233–1242, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Y. Oudit, M. A. Crackower, U. Eriksson et al., “Phosphoinositide 3-Kinase γ-Deficient Mice Are Protected From Isoproterenol-Induced Heart Failure,” Circulation, vol. 108, no. 17, pp. 2147–2152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Zhou, L. J. Wu, S. I. Tashiro, S. Onodera, F. Uchiumi, and T. Ikejima, “Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle,” Biological and Pharmaceutical Bulletin, vol. 29, no. 9, pp. 1900–1905, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Zhou, L. J. Wu, S. I. Tashiro, S. Onodera, F. Uchiumi, and T. Ikejima, “Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent,” Acta Pharmacologica Sinica, vol. 28, no. 6, pp. 803–810, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Y. Zhao, G. Y. Li, Y. Liu et al., “Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo,” British Journal of Pharmacology, vol. 154, no. 1, pp. 105–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. G. Zhang, H. G. Zhang, G. Y. Zhang et al., “Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action,” Clinical and Experimental Pharmacology and Physiology, vol. 35, no. 10, pp. 1238–1244, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. H. P. Zhao, L. Dan, W. Zhang et al., “Ginsenoside-Rb1 attenuates dilated cardiomyopathy in cTnTR141W Transgenic mouse,” Journal of Pharmacological Sciences, vol. 112, no. 2, pp. 214–222, 2010. View at Publisher · View at Google Scholar
  11. S. Park, I. S. Ahn, D. Y. Kwon, B. S. Ko, and W. K. Jun, “Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance β-cell insulin secretion and viability in min6 cells via PKA-dependent pathways,” Bioscience, Biotechnology and Biochemistry, vol. 72, no. 11, pp. 2815–2823, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. El-Naggar, Y. Liu, and D. C. Dean, “Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation,” Molecular and Cellular Biology, vol. 29, no. 21, pp. 5710–5717, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. Q. S. Jiang, X. N. Huang, G. Z. Yang, X. Y. Jiang, and Q. X. Zhou, “Inhibitory effect of ginsenoside Rb1 on calcineurin signal pathway in cardiomyocyte hypertrophy induced by prostaglandin F2α,” Acta Pharmacologica Sinica, vol. 28, no. 8, pp. 1149–1154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. H. L. Kong, Z. Q. Li, Y. J. Zhao et al., “Ginsenoside Rb1 protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening,” Acta Pharmacologica Sinica, vol. 31, no. 6, pp. 687–695, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Hu, X. Jiao, E. Gao et al., “Chronic β-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress,” Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 2, pp. 469–475, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. W. H. Zhou, M. R. Du, L. Dong et al., “Cyclosporin A increases expression of matrix metalloproteinase 9 and 2 and invasiveness in vitro of the first-trimester human trophoblast cells via the mitogen-activated protein kinase pathway,” Human Reproduction, vol. 22, no. 10, pp. 2743–2750, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Ding, J. I. Abe, H. Wei et al., “A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 41, pp. 14771–14776, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Yan, B. Ding, T. Shishido et al., “Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop,” Circulation Research, vol. 100, no. 4, pp. 510–519, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. V. G. Sharov, H. N. Sabbah, H. Shimoyama, A. V. Goussev, M. Lesch, and S. Goldstein, “Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure,” American Journal of Pathology, vol. 148, no. 1, pp. 141–149, 1996. View at Google Scholar · View at Scopus
  20. J. Narula, N. Haider, R. Virmani et al., “Apoptosis in myocytes in end-stage heart failure,” New England Journal of Medicine, vol. 335, no. 16, pp. 1182–1189, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Granata, L. Trovato, M. P. Gallo et al., “Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart,” Cardiovascular Research, vol. 83, no. 2, pp. 303–312, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Zaugg, W. Xu, E. Lucchinetti, S. A. Shafiq, N. Z. Jamali, and M. A. Q. Siddiqui, “β-Adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes,” Circulation, vol. 102, no. 3, pp. 344–350, 2000. View at Google Scholar · View at Scopus
  23. J. N. Cohn, T. B. Levine, and M. T. Olivari, “Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure,” New England Journal of Medicine, vol. 311, no. 13, pp. 819–823, 1984. View at Google Scholar · View at Scopus
  24. J. M. Cruickshank, “Beta-blockers and heart failure,” Indian heart journal, vol. 62, no. 2, pp. 101–110, 2010. View at Google Scholar · View at Scopus
  25. S. Pasupathy and S. Homer-Vanniasinkam, “Ischaemic preconditioning protects against Ischaemia/Reperfusion injury: emerging concepts,” European Journal of Vascular and Endovascular Surgery, vol. 29, no. 2, pp. 106–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Tomita, M. Nazmy, K. Kajimoto, G. Yehia, C. A. Molina, and J. Sadoshima, “Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to β-adrenergic receptor stimulation,” Circulation Research, vol. 93, no. 1, pp. 12–22, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Liang, S. Ge, L. Yang et al., “Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures,” Brain Research, vol. 1357, pp. 19–25, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. F. Xue, Z. J. Liu, J. F. Hu, H. Chen, J. T. Zhang, and N. H. Chen, “Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway,” Brain Research, vol. 1106, no. 1, pp. 91–98, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Lu, H. Lian, X. Zhang et al., “LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice,” PLoS ONE, vol. 5, no. 12, Article ID e15167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. B. F. Lv, C. F. Yu, Y. Y. Chen et al., “Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis,” Apoptosis, vol. 11, no. 9, pp. 1489–1501, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Saji, Y. Fukumoto, J. Suzuki, S. Fukui, J. Nawata, and H. Shimokawa, “Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in rats,” Tohoku Journal of Experimental Medicine, vol. 213, no. 2, pp. 139–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Q. Tan, J. X. Wang, Z. Q. Lin, Y. R. Li, Y. Lin, and P. F. Li, “Novel cardiac apoptotic pathway the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin,” Circulation, vol. 118, no. 22, pp. 2268–2276, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. S. N. Orlov, N. Thorin-Trescases, N. O. Dulin et al., “Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3,” Cell Death and Differentiation, vol. 6, no. 7, pp. 661–672, 1999. View at Google Scholar · View at Scopus