Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
Chemical profile and cytotoxicity of the aqueous extract of P. lactiflora. (a) Chromatographic patterns from HPLC analysis (230 nm) showed peaks compatible with paeoniflorin, albiflorin and garlic acid. (b) The relative amount of above molecules in the extract. (c) Cytotoxicity of the aqueous extract of P. lactiflora, paeoniflorin, garlic acid, albiflorin, and SAHA against HEK-293 and SH-SY5Y cells using MTT viability assay. The IC50 of each herb/compound was shown under the columns. To normalize, the relative viability in untreated cells is set as 100%. The red line represents 50% viability.