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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 471659, 11 pages
Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
1Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan
2Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan
Received 29 October 2012; Accepted 19 January 2013
Academic Editor: Carlo Ventura
Copyright © 2013 Kuo-Hsuan Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Matilla-Dueñas, M. Corral-Juan, V. Volpini, and I. Sanchez, “The spinocerebellar ataxias: clinical aspects and molecular genetics,” Advances in Experimental Medicine and Biology, vol. 724, pp. 351–374, 2012.
- Y. Kawaguchi, T. Okamoto, M. Taniwaki et al., “CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1,” Nature Genetics, vol. 8, no. 3, pp. 221–228, 1994.
- H. T. Orr, M. Y. Chung, S. Banfi et al., “Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1,” Nature Genetics, vol. 4, no. 3, pp. 221–226, 1993.
- S. M. Pulst, A. Nechiporuk, T. Nechiporuk et al., “Moderate expansion of a normally biallelic trinucleotide repeat in spinooerebellar ataxia type,” Nature Genetics, vol. 14, no. 3, pp. 269–276, 1996.
- O. Zhuchenko, J. Bailey, P. Bonnen et al., “Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α(1A)-voltage-dependent calcium channel,” Nature Genetics, vol. 15, no. 1, pp. 62–69, 1997.
- G. David, N. Abbas, G. Stevanin et al., “Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion,” Nature Genetics, vol. 17, no. 1, pp. 65–70, 1997.
- R. Koide, S. Kobayashi, T. Shimohata et al., “A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?” Human Molecular Genetics, vol. 8, no. 11, pp. 2047–2053, 1999.
- R. Koide, T. Ikeuchi, O. Onodera et al., “Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA),” Nature Genetics, vol. 6, no. 1, pp. 9–13, 1994.
- H. Y. Zoghbi and H. T. Orr, “Polyglutamine diseases: protein cleavage and aggregation,” Current Opinion in Neurobiology, vol. 9, no. 5, pp. 566–570, 1999.
- J. R. Gatchel and H. Y. Zoghbi, “Diseases of unstable repeat expansion: mechanisms and common principles,” Nature Reviews Genetics, vol. 6, no. 10, pp. 743–755, 2005.
- A. Solans, A. Zambrano, M. Rodríguez, and A. Barrientos, “Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III,” Human Molecular Genetics, vol. 15, no. 20, pp. 3063–3081, 2006.
- E. J. Bennett, T. A. Shaler, B. Woodman et al., “Global changes to the ubiquitin system in Huntington's disease,” Nature, vol. 448, no. 7154, pp. 704–708, 2007.
- S. M. Chafekar and M. L. Duennwald, “Impaired heat shock response in cells expressing full-length polyglutamine-expanded Huntingtin,” PLoS ONE, vol. 7, no. 5, Article ID e37929, 2012.
- T. T. Ou, C. H. Wu, J. D. Hsu, C. C. Chyau, H. J. Lee, and C. J. Wang, “Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo,” Journal of Ethnopharmacology, vol. 135, no. 1, pp. 162–172, 2011.
- H. Q. Liu, W. Y. Zhang, X. T. Luo, Y. Ye, and X. Z. Zhu, “Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor,” British Journal of Pharmacology, vol. 148, no. 3, pp. 314–325, 2006.
- D. Z. Liu, J. Zhu, D. Z. Jin et al., “Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease,” Journal of Ethnopharmacology, vol. 112, no. 2, pp. 327–332, 2007.
- S. Z. Zhong, Q. H. Ge, Q. Li, R. Qu, and S. P. Ma, “Peoniflorin attentuates Aβ(1-42)-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats,” Journal of the Neurological Sciences, vol. 280, no. 1-2, pp. 71–78, 2009.
- M. H. Jeon, H. J. Kwon, J. S. Jeong, Y. M. Lee, and S. P. Hong, “Detection of albiflorin and paeoniflorin in Paeoniae Radix by reversed-phase high-performance liquid chromatography with pulsed amperometric detection,” Journal of Chromatography A, vol. 1216, no. 21, pp. 4568–4573, 2009.
- S. L. Li, J. Z. Song, F. F. K. Choi et al., “Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 49, no. 2, pp. 253–266, 2009.
- Y. Zhang, S. Koushik, R. Dai, and N. F. Mivechi, “Structural organization and promoter analysis of murine heat shock transcription factor-1 gene,” Journal of Biological Chemistry, vol. 273, no. 49, pp. 32514–32521, 1998.
- M. He, H. Guo, X. Yang et al., “Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population,” PloS One, vol. 5, no. 3, p. e9684, 2010.
- Y.-R. Wu, C.-K. Wang, C.-M. Chen et al., “Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease,” Human Genetics, vol. 114, no. 3, pp. 236–241, 2004.
- L.-C. Lee, C.-M. Chen, H.-C. Wang et al., “Role of the CCAAT-binding protein NFY in SCA17 pathogenesis,” PLoS One, vol. 7, no. 4, Article ID e35302, 2012.
- S. Flis and J. Spławiński, “Inhibitory effects of 5-fluorouracil and oxaliplatin on human colorectal cancer cell survival are synergistically enhanced by sulindac sulfide,” Anticancer Research, vol. 29, no. 1, pp. 435–441, 2009.
- A. Haacke, S. A. Broadley, R. Boteva, N. Tzvetkov, F. U. Hartl, and P. Breuer, “Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3,” Human Molecular Genetics, vol. 15, no. 4, pp. 555–568, 2006.
- M. Mielcarek, C. L. Benn, S. A. Franklin, et al., “SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease,” PLoS One, vol. 6, no. 11, Article ID e27746, 2011.
- K. Iwasaki, S. Kato, Y. Monma et al., “A pilot study of Banxia Houpu Tang, a traditional Chinese medicine, for reducing pneumonia risk in older adults with dementia,” Journal of the American Geriatrics Society, vol. 55, no. 12, pp. 2035–2040, 2007.
- T. Satoh, T. Takahashi, K. Iwasaki et al., “Traditional Chinese medicine on four patients with Huntington's disease,” Movement Disorders, vol. 24, no. 3, pp. 453–455, 2009.
- T. Okabe, M. Fujisawa, T. Sekiya, Y. Ichikawa, and J. Goto, “Successful treatment of spinocerebellar ataxia 6 with medicinal herbs,” Geriatrics & Gerontology International, vol. 7, no. 2, pp. 195–197, 2007.
- D.-Y. He and S.-M. Dai, “Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine,” Frontiers in Pharmacology, vol. 2, article 10, 2011.
- S. H. Kim, M. K. Lee, K. Y. Lee, S. H. Sung, J. Kim, and Y. C. Kim, “Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 5, pp. 1138–1140, 2009.
- D. Yan, K. Saito, Y. Ohmi, N. Fujie, and K. Ohtsuka, “Paeoniflorin, a novel heat shock protein-inducing compound,” Cell Stress and Chaperones, vol. 9, no. 4, pp. 378–389, 2004.
- M. Fujimoto, E. Takaki, T. Hayashi et al., “Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models,” Journal of Biological Chemistry, vol. 280, no. 41, pp. 34908–34916, 2005.
- N. Fujikake, Y. Nagai, H. A. Popiel, Y. Okamoto, M. Yamaguchi, and T. Toda, “Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones,” Journal of Biological Chemistry, vol. 283, no. 38, pp. 26188–26197, 2008.
- J. M. Warrick, H. Y. E. Chan, G. L. Gray-Board, Y. Chai, H. L. Paulson, and N. M. Bonini, “Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70,” Nature Genetics, vol. 23, no. 4, pp. 425–428, 1999.
- C. J. Cummings, Y. Sun, P. Opal et al., “Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice,” Human Molecular Genetics, vol. 10, no. 14, pp. 1511–1518, 2001.
- S. A. Kim, J. H. Yoon, D. K. Kim, S. G. Kim, and S. G. Ahn, “CHIP interacts with heat shock factor 1 during heat stress,” FEBS Letters, vol. 579, no. 29, pp. 6559–6563, 2005.
- L. C. Lee, C. M. Chen, F. L. Chen et al., “Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis,” Clinica Chimica Acta, vol. 400, no. 1-2, pp. 56–62, 2009.
- C. M. Chen, L. C. Lee, B. W. Soong et al., “SCA17 repeat expansion: mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications,” Clinica Chimica Acta, vol. 411, no. 5-6, pp. 375–380, 2010.