Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 2

Research Article

Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel

Figure 2

Effect of GA on the slow and rapid components of the delayed rectifier K+ current in guinea pig ventricular myocytes. (a) Representative traces of the rapid ( ) and slow ( ) components of the delayed rectifier K+ channel tail currents before and after treatment with 10 μM GA and 2 μM E-4031. The effects of 1, 5, and 10 μM GA and 2 μM E-4031 on (b) and (c), normalized relative to the control current ( , ). The tail current amplitudes were differences between peak outward current and the steady state current at the end of the repolarizing voltage pulses. (* , ** ).

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