Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel
Figure 6
Effect of GA on kinetic time constants. (a) Representative current traces for the onset of inactivation of the HERG current using the protocol are shown on the figure. The time constants for the onset of inactivation were obtained by fitting the exponential function to the decaying current traces during the third pulse of the protocol. (b) Representative current traces for HERG current recovery from inactivation elicited by the protocol are shown on the figure. (c) Time constants for onset of inactivation were plotted against membrane potential. Data were expressed as mean ± SEM (, ). (d) Time constants for deactivation in the absence or presence of 5 μM GA (, ). Solid lines represent fits of a single exponential function to the descending phase of the tail current. Data were expressed as mean ± SEM, and statistical comparisons were made using a two-tailed Student’s t-test. (*, **).
