<i>Paeonia lactiflora</i> Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway

<table>Effects of PLex and PF on cerebral infarction induced by ischemia/reperfusion injury. Coronal section of brain after ischemia for 90 min and followed by reperfusion for 24 h. Then staining with TTC, the infarction areas appeared white and noninfarction areas appeared red-purple in color. S1→S6: slices from frontal lobe. (a) Treatment with PLex and PF. (b) Statistic percentage of cerebral infarction area of PLex and PF. Scale bar = 1 cm. *<svg height="11.375" id="M4" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with the control group (<svg height="11.225" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>).</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: <i>Paeonia lactiflora</i> Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway 

Figure 2 | Paeonia lactiflora Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway 