Methanol Extract of Artemisia apiacea Hance Attenuates the Expression of Inflammatory Mediators via NF-κB Inactivation
Figure 5
Inhibition of carrageenan-induced paw edema formation by MEAH. MEAH, dissolved in 40% PEG, was orally administered to rats at 0.3 or 1.0 g/kg/day prior to the induction of paw edema for three days. Paw edema was induced by subcutaneous injection of 1% carrageenan solution as described in methods. The swelling volume of paw was measured up to 4 h after 0.5 h carrageenan injection at intervals of 1 h by using plethysmometer. Dexamethasone (1 mg/kg, p.o.) was used as a positive drug. Data represent mean ± S.D. of five animals (significant as compared with carrageenan-treated group, **; *, paw volume at 0 h in carrageenan-treated rat = 100%).
