Methanol Extract of Artemisia apiacea Hance Attenuates the Expression of Inflammatory Mediators via NF-κB Inactivation

Table 1

Changes in the histomorphometrical analysis of hind paw skins.

Groups	Thickness; (epidermis to dermis, mm)	Infiltrated inflammatory cells; (cells/mm^2 of dermis)
Dorsum  pedis skin
Carrageenan	2.362±0.168	118.60±10.21
Carrageenan + dexamethasone	0.754±0.082^∗∗	31.00±5.96^∗∗
Carrageenan + MEAH 1.0 g/kg	1.800±0.128^∗∗	43.40±5.23^∗∗
Carrageenan + MEAH 0.3 g/kg	2.052±0.090^∗∗	87.80±10.71^∗∗
Ventrum  pedis skin
Carrageenan	1.268±0.039	1263.60±179.74
Carrageenan + dexamethasone	0.776±0.048^∗∗	86.40±12.70^∗∗
Carrageenan + MEAH 1.0 g/kg	0.900±0.052^∗∗	481.00±55.86^∗∗
Carrageenan + MEAH 0.3 g/kg	1.028±0.081^∗∗	882.80±109.97^∗∗

The thicknesses of dorsum and ventrum  pedis and infiltrated inflammatory cells were measured using automated image analyzer. All values are expressed as mean ± S.D. of five rat hind paws (significant as compared with carrageenan-treated group, **𝑃<0.01).