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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 496036, 9 pages
Research Article

Effects of “Bu Shen Huo Xue Decoction” on the Endometrial Morphology and Expression of Leukaemia Inhibitory Factor in the Rat Uterus during the Oestrous Cycle

1Reproductive Endocrinology Centre, Dongfang Hospital of Beijing University of Chinese Medicine, No. 6 Fangxingyuan 1 Qu, Fengtai District, Beijing 100078, China
2Dongzhimen Hospital of Beijing University of Chinese Medicine, No. 5 Haiyuncang, Beijing 100700, China

Received 15 February 2013; Revised 27 March 2013; Accepted 7 April 2013

Academic Editor: Chris J. Branford-White

Copyright © 2013 Xin Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to explore the positive effects of Bu Shen Huo Xue Decoction (BSHXF) on assisted reproduction. The study aimed to evaluate whether BSHXD could improve endometrial morphology and increase the expression of LIF in a gonadotrophin-releasing hormone agonists (GnRHa) long protocol-induced rat model during metestrus, diestrus, proestrus, and oestrus. The BSHXD group presented significantly increased endometrium thickness and decreased MVD compared with the GnRHa long protocol group. In addition, the expression of LIF was significantly higher in the BSHXD group. There were no significant differences between the control group and the BSHXD group in terms of MVD and LIF expression. These results suggested that BSHXD can improve the endometrium development, reduce the abnormal angiogenesis, and increase the expression of receptivity markers in a GnRHa long protocol-induced rat model during the oestrous cycle, which might result in an endometrial environment better suited for female reproduction.