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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 502727, 7 pages
Research Article

Effect of Eucalyptus Oil Inhalation on Pain and Inflammatory Responses after Total Knee Replacement: A Randomized Clinical Trial

1Department of Basic Nursing Science, School of Nursing, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-713, Republic of Korea
2Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea
3KT&G Research Institute, Daejeon 305-805, Republic of Korea

Received 2 April 2013; Revised 7 June 2013; Accepted 7 June 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Yang Suk Jun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Eucalyptus oil has been reported effective in reducing pain, swelling, and inflammation. This study aimed to investigate the effects of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement (TKR) surgery. Participants were randomized 1 : 1 to intervention group (eucalyptus inhalation group) or control group (almond oil inhalation group). Patients inhaled eucalyptus or almond oil for 30 min of continuous passive motion (CPM) on 3 consecutive days. Pain on a visual analog scale (VAS), blood pressure, heart rate, C-reactive protein (CRP) concentration, and white blood cell (WBC) count were measured before and after inhalation. Pain VAS on all three days ( ) and systolic ( ) and diastolic ( ) blood pressure on the second day were significantly lower in the group inhaling eucalyptus than that inhaling almond oil. Heart rate, CRP, and WBC, however, did not differ significantly in the two groups. In conclusion, inhalation of eucalyptus oil was effective in decreasing patient's pain and blood pressure following TKR, suggesting that eucalyptus oil inhalation may be a nursing intervention for the relief of pain after TKR.