Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 503043, 11 pages
http://dx.doi.org/10.1155/2013/503043
Research Article

Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells

1Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, 90 Chilam-dong, Jinju 660-702, Republic of Korea
2The Fifth Hospital of Shijizhuang, Shijizhuang 050021, China
3Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea
4Department of Pathology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea
5Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul 660-702, Republic of Korea
6Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School, Busan 614-052, Republic of Korea
7School of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea
8Division of Applied Life Science (BK 21 Program), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea
9Department of Chemistry, Research Institute of Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea

Received 29 March 2013; Accepted 28 May 2013

Academic Editor: Shrikant Anant

Copyright © 2013 Jing Nan Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Okada, “Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis,” The Japanese Journal of Cancer and Chemotherapy, vol. 26, no. 14, pp. 2247–2252, 1999. View at Google Scholar · View at Scopus
  2. A. D. Rhim, E. T. Mirek, N. M. Aiello et al., “EMT and dissemination precede pancreatic tumor formation,” Cell, vol. 148, no. 1-2, pp. 349–361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. K.-H. Chun, J. W. Kosmeder II, S. Sun et al., “Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells,” Journal of the National Cancer Institute, vol. 95, no. 4, pp. 291–302, 2003. View at Google Scholar · View at Scopus
  4. H. Hatcher, R. Planalp, J. Cho, F. M. Torti, and S. V. Torti, “Curcumin: from ancient medicine to current clinical trials,” Cellular and Molecular Life Sciences, vol. 65, no. 11, pp. 1631–1652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C.-L. Chen, S. S. Liu, S.-M. Ip, L. C. Wong, T. Y. Ng, and H. Y. S. Ngan, “E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours,” European Journal of Cancer, vol. 39, no. 4, pp. 517–523, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Y. Shin, W. S. Lee, S. H. Kim et al., “Anti-invasive activity of anthocyanins isolated from vitis coignetiae in human hepatocarcinoma cells,” Journal of Medicinal Food, vol. 12, no. 5, pp. 967–972, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Y. Shin, C. H. Ryu, W. S. Lee et al., “Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from meoru,” Annals of the New York Academy of Sciences, vol. 1171, pp. 137–148, 2009. View at Google Scholar
  8. D. Y. Shin, W. S. Lee, J. N. Lu et al., “Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK,” International Journal of Oncology, vol. 35, no. 6, pp. 1499–1504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Vihinen and V.-M. Kähäri, “Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets,” International Journal of Cancer, vol. 99, no. 2, pp. 157–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. E. I. Deryugina and J. P. Quigley, “Matrix metalloproteinases and tumor metastasis,” Cancer and Metastasis Reviews, vol. 25, no. 1, pp. 9–34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Rangaswami, A. Bulbule, and G. C. Kundu, “Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IκBα kinase-dependent nuclear factor κB-mediated promatrix metalloproteinase-9 activation,” Journal of Biological Chemistry, vol. 279, no. 37, pp. 38921–38935, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. U. Gaur and B. B. Aggarwal, “Regulation of proliferation, survival and apoptosis by members of the TNF superfamily,” Biochemical Pharmacology, vol. 66, no. 8, pp. 1403–1408, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. B. B. Aggarwal, “Nuclear factor-κB: the enemy within,” Cancer Cell, vol. 6, no. 3, pp. 203–208, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. T. D. Gilmore, “Introduction to NF-κB: players, pathways, perspectives,” Oncogene, vol. 25, no. 51, pp. 6680–6684, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. S. Jope, C. J. Yuskaitis, and E. Beurel, “Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics,” Neurochemical Research, vol. 32, no. 4-5, pp. 577–595, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Li, B. Welm, K. Podsypanina et al., “Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 26, pp. 15853–15858, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Y. Chu, J. Hens, T. Andl et al., “Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis,” Development, vol. 131, no. 19, pp. 4819–4829, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Paul and A. Dey, “Wnt signaling and cancer development: therapeutic implication,” Neoplasma, vol. 55, no. 3, pp. 165–176, 2008. View at Google Scholar · View at Scopus
  19. W. Lam, H. Chan, M. Yang, S. Cheng, and W. Fong, “Synergism of energy starvation and dextran-conjugated doxorubicin in the killing of multidrug-resistant KB carcinoma cells,” Anti-Cancer Drugs, vol. 10, no. 2, pp. 171–178, 1999. View at Google Scholar · View at Scopus
  20. M.-L. Lin, Y.-C. Lu, J.-G. Chung et al., “Down-regulation of MMP-2 through the p38 MAPK-NF-κB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion,” Molecular Carcinogenesis, vol. 49, no. 9, pp. 783–797, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. K.-S. Chun and Y.-J. Surh, “Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention,” Biochemical Pharmacology, vol. 68, no. 6, pp. 1089–1100, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. E. V. Schmidt, “The role of c-myc in regulation of translation initiation,” Oncogene, vol. 23, no. 18, pp. 3217–3221, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Wu and B. P. Zhou, “TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion,” British Journal of Cancer, vol. 102, no. 4, pp. 639–644, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Aggarwal, H. Ichikawa, Y. Takada, S. K. Sandur, S. Shishodia, and B. B. Aggarwal, “Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation,” Molecular Pharmacology, vol. 69, no. 1, pp. 195–206, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Barrallo-Gimeno and M. A. Nieto, “The Snail genes as inducers of cell movement and survival: implications in development and cancer,” Development, vol. 132, no. 14, pp. 3151–3161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Toyoshima, N. Tanaka, J. Aoki et al., “Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and β-catenin,” Cancer Research, vol. 67, no. 11, pp. 5162–5171, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Chen, K. A. Bower, M. Xu et al., “Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 beta,” Neurotoxicity Research, vol. 15, no. 4, pp. 321–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. T. S. Hudson, D. K. Hartle, S. D. Hursting et al., “Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms,” Cancer Research, vol. 67, no. 17, pp. 8396–8405, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Rajakangas, M. Misikangas, E. Päivärinta, and M. Mutanen, “Chemoprevention by white currant is mediated by the reduction of nuclear β-catenin and NF-κB levels in Min mice adenomas,” European Journal of Nutrition, vol. 47, no. 3, pp. 115–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Correia, M. Cravo, P. Marques-Vidal et al., “Serum concentrations of TNF-alpha as a surrogate marker for malnutrition and worse quality of life in patients with gastric cancer,” Clinical Nutrition, vol. 26, no. 6, pp. 728–735, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Tas, D. Duranyildiz, A. Argon et al., “Serum levels of leptin and proinflammatory cytokines in advanced-stage non-small cell lung cancer,” Medical Oncology, vol. 22, no. 4, pp. 353–358, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Jamnitski, J. H. Levels, I. A. Oever, and M. T. Nurmohamed, “High-density lipoprotein profiling changes in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a cohort study,” Journal of Rheumatology, vol. 40, no. 6, pp. 825–830, 2013. View at Google Scholar
  33. M. Ding, R. Feng, S. Y. Wang et al., “Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity,” Journal of Biological Chemistry, vol. 281, no. 25, pp. 17359–17368, 2006. View at Publisher · View at Google Scholar · View at Scopus